急性轻症胰腺炎与非酒精性脂肪肝的关系  

Relationship between acute mild pancreatitis and non-alcoholic fatty liver

作　　者：姚俊[1] 许亚平[1] 周春锁[1] 陶立生[1] 李琴[1] 

机构地区：[1]镇江市第一人民医院消化科,江苏镇江212002

出　　处：《中国临床研究》2016年第3期318-320,共3页Chinese Journal of Clinical Research

基　　金：江苏省自然科学基金资助项目(BK2011482);江苏省镇江市卫生局指导课题(FZ2011051)

摘　　要：目的探讨急性轻症胰腺炎与非酒精性脂肪肝的关系。方法收集2014年7月至2015年7月收治的154例无酗酒习惯患有急性轻症胰腺炎患者的完整病历资料,154例患者入院时均进行血尿淀粉酶、肝功能以及血甘油三酯检查,同时对肝胆胰进行CT扫描检查。结果 154例急性轻症胰腺炎患者中有91例(59.1%)伴有脂肪肝,无脂肪肝63例(40.9%);有脂肪肝者血甘油三酯、天冬氨酸氨基转移酶(AST)/丙氨酸氨基转氨酶(ALT)、血总胆红素水平均高于无脂肪肝者,差异均有统计学意义(P均<0.05)。91例脂肪肝患者中,Ⅰ级56例,Ⅱ23例,Ⅲ级12例;随着脂肪肝分级程度的加重,诊断急性胰腺炎的生化学指标血、尿淀粉酶水平也不断升高(P均<0.05)。结论高脂血症、肝酶异常、胆红素增高与脂肪肝及急性胰腺炎均有关联,脂肪肝与胰腺炎的发生可能存在相关性。Objective To study the relationship between acute mild pancreatitis and non-alcoholic fatty liver. Methods The complete medical records of 154 patients with acute mild pancreatitis without drinking habits who were treated in Zhenjiang first people＇s hospital from July 2014 to June 2015 were collected. The examinations of serum and urine amylase,liver function,blood triglyceride and hepatobiliary and pancreatic CT scan were performed on admission in all patients. Results Out of 154 patients with acute mild pancreatitis,91 were combined with fatty liver（ 59. 1%）,and 63 were not combined with fatty liver（ 40. 9%）. The levels of blood triglyceride,the ratio of aspartate transaminase（ AST） to alanine aminotransferase（ ALT） and serum total bilirubin in patients with fatty liver were all significantly higher than those in patients without fatty liver（ all P 〈0. 05）. Out of 91 patients with fatty liver,56 wereⅠgrade; 23 wereⅡgrade; 12 were Ⅲ grade for grading of fatty liver. The levels of serum and urine amylase（ biochemistry indexes for the diagnosis of acute pancreatitis） rose with the increase of fatty liver grading（ all P 〈0. 05）. Conclusion Hyperlipemia,abnormal liver enzymes and high bilirubin were associated with acute pancreatitis,and there may be a correlation between fatty liver and acute mild pancreatitis.

关 键 词：急性胰腺炎 轻症 脂肪肝 甘油三酯 高脂血症 淀粉酶 胆红素 

分 类 号：R576[医药卫生—消化系统] R575.5[医药卫生—内科学]