代谢组学技术在中药药性理论研究中的应用概述  

Overview on application of metabonomics in study on Chinese materia medica property theory

作　　者：郭慧[1] 崔扬[1] 王秋红[1] 匡海学[1] 

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室,黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040

出　　处：《中草药》2016年第3期363-368,共6页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展计划(“973”计划)项目(2013CB531801)

摘　　要：代谢组学作为系统生物学的重要组成部分,其研究思想与中医药研究思想的整体观相似。近几年,随着代谢组学技术的蓬勃发展,其在中药现代研究中的应用越来越广泛。通过对代谢组学起源、发展、研究内容及方法进行简要概述,并对其在中药药性理论,包括四气五味、升降沉浮、归经、有毒无毒、配伍、禁忌中的应用进行概述,初步分析并总结了代谢组学应用于中药药性理论研究所存在的问题及发展趋势。Metabonomics as an important component of systems biology,the research idea is similar to the overall concept in the research of traditional Chinese medicine（TCM）.In recent years,with the vigorous development of metabonomics,its application is more and more widely in modern research of Chinese material medica（CMM）.In this paper,based on the introduction of origin,development,research content,and method of metabonomics,and at the same time its application on medicinal properties in TCM theory,including four Qi,five tastes,meridian entry,direction of medicinal actions（upward,downward,outward,and inward）,toxicity,compatibility of medicines,and the contraindication of application,are summarized.The preliminary analysis and sums up of research problems and development trend on the metabonomics applying in TCM property theory have been brought forward.

关 键 词：代谢组学 四气五味 升降沉浮 归经 毒性 配伍 用药禁忌 

分 类 号：R285[医药卫生—中药学]