VEGF、TP、CyclinD1与食管癌预后相关性的临床观察  

The clinical observation on correlation between the prognosis of esophageal carcinoma and VEGF, TP, CyclinD1

作　　者：李铁志[1] 石彦涛[1] 刘瑞林[1] 马晓钰[1] 高少林[1] 郑兆伟 张合林[1] 

机构地区：[1]河北医科大学第二医院胸外科,石家庄050031

出　　处：《中国医学前沿杂志（电子版）》2016年第2期57-60,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨血管内皮生长因子(VEGF)、胸苷磷酸化酶(TP)以及细胞周期蛋白D1(CyclinD1)的表达对食管癌患者预后的影响。方法利用免疫组织化学相关检测技术研究食管癌组织中VEGF、TP以及CyclinD1蛋白的表达情况,研究此类细胞因子和蛋白的高表达与食管癌预后的相关性。结果发生淋巴结转移的食管癌组织中CyclinD1表达率高于未发生淋巴结转移的组织;低分化、癌组织浸润至浆膜患者的CyclinD1表达率高于中、高分化以及癌组织未浸润至浆膜患者。VEGF的表达水平与食管癌组织的淋巴结转移情况、浆膜浸润与否、肿瘤直径以及分化程度呈明显相关性(P<0.05);TP的表达水平与食管癌组织的淋巴结转移情况、组织学分化程度以及远处转移呈明显相关性(P<0.05)。结论 VEGF、TP以及CyclinD1的高表达与食管癌淋巴结转移以及组织分化程度呈明显正相关,可以作为评估食管癌预后的指标,值得临床推广应用。Objective To explore the effect of vascular endothelial growth factor（VEGF）, thymidine phosphorylase（TP） and CyclinD1（CyclinD1） expression on the prognosis of esophageal carcinoma patients. Method Used immunohistochemistry detecting technique to study the expression of VEGF, TP and CyclinD1 of esophageal tissue, discussed the correlation between the high expression of cytokines and protein and the prognosis of esophageal carcinoma. Result The expression rate of CyclinD1 in the esophageal carcinoma tissue occurred lymph node metastasis was higher than none of lymph node metastasis, the expression rates of CyclinD1 in the poorly differentiated and carcinoma invasion to serosa were also higher than the welldifferentiated and carcinoma not infiltrated to serous; the expression rate of VEGF was significantly correlated to the lymph node metastasis of esophageal carcinoma, serous infiltration or not, tumor diameter and degree of differentiation（P〈0.05）; the expression rate of TP was significantly correlated to the lymph node metastasis of esophageal carcinoma, degree of histological differentiation and distant metastasis（P〈0.05）. ConclusionThe high expression of VEGF, TP and CyclinD1 is positively correlated with lymph node metastasis and tissue differentiation of esophageal carcinoma, it can be used as an index to evaluate the prognosis of esophageal cancer, it is worthy of clinical application.

关 键 词：血管内皮生长因子 胸苷磷酸化酶 细胞周期蛋白D1 食管癌 预后 

分 类 号：R735.1[医药卫生—肿瘤]