腮腺原始神经外胚层肿瘤2例临床病理观察  

Primitive neuroectodermal tumors in parotid gland: clinicopathological features of two cases

作　　者：盛莹[1] 姜波[1] 赵建业[2] 

机构地区：[1]解放军第159医院病理科,河南驻马店463000 [2]第四军医大学唐都医院病理科,西安710038

出　　处：《诊断病理学杂志》2016年第3期176-178,182,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨腮腺原始神经外胚层肿瘤(PNET)的病理诊断及鉴别诊断。方法收集2例原发于腮腺的PNET的临床资料,观察组织学、病理学形态及免疫组化染色,并复习相关文献。结果镜下观察,瘤组织由形态一致的小圆细胞组成,呈实性片状或乳头状排列,局部可见菊形团样结构。免疫组化:瘤细胞CD99、vimentin、calponin、FLI-1、S-100、CD56、NSE和Syn(+)。结论原发于腮腺的PNET是一种极少见的神经内分泌肿瘤,确诊需要依靠病理组织学及免疫组化标记,并需与原发腮腺的其他小圆细胞肿瘤鉴别。Objective To observe the clinicopathological and immunohistochemical features of peripheral primitive neuroectodermal tumor（ PNET） in parotid gland. Methods This was a retrospective study of 2 patients with PNET of parotid gland and we analyzed for the clinical symptom,histological features and immunohistochemistry. Results Tumors were characterized by small round cells,arranged in sheets or closely packed nests. They were separated by fibrous septa. The Homer Wright-type rosettes were seen in all cases. CD99,vimtenin,calponin,FLI-1,S-100,CD56,NSE and Syn were all positive. Conclusion PNET is a rare neuroendocrine tumor in the parotid gland and its correct diagnosis relies on the pathological examination and immunohistochemical staining,and it is also needed to differentiate it from other small round cell tumor in parotid gland.

关 键 词：腮腺 PNET 免疫组化 鉴别诊断 

分 类 号：R739.87[医药卫生—肿瘤]