精神分裂症患者服药依从性的测量方法  

Strategies for measuring medication adherence in patients with schizophrenia

作　　者：王云芳[1] 黄志平[2] 徐东[3,4] 龚雯洁[1] 唐媛[1] 肖水源[1] 

机构地区：[1]中南大学湘雅公共卫生学院,长沙410008 [2]中南大学研究生院,长沙410083 [3]中山大学公共卫生学院,广州510080 [4]中山大学国家治理研究院全球卫生研究中心,广州510080

出　　处：《中南大学学报（医学版）》2016年第2期218-224,共7页Journal of Central South University ：Medical Science

基　　金：美国中华医学基金会(12-114);美国国立卫生研究院Fogarty国际中心(R25TW009345);中南大学研究生自主探索创新项目(201422ts311)~~

摘　　要：大多数精神分裂症患者需要长期维持治疗,服药依从性是影响精神分裂症患者预后及转归非常重要的因素。笔者采用关键词检索中英文数据库,对检索到的文献进行初筛,然后回顾已检索文献的参考文献,综合专家建议,纳入样本人群为精神分裂症患者并且报告了信度和效度的参考文献,共11篇。将这11篇文献中服药依从性的测量方法进行归类,可分为主观和客观两类,主观方法包括药物态度问卷、服药影响因素评定量表、服药影响因素和信念的简易评价、简明依从性评定量表、药物依从性评定量表和Morisky量表;客观方法包括血(尿)药浓度的检测、药片计数、药房记录和电子药瓶计数。精神分裂症患者服药依从性的测量方法都有其局限性,研究者在进行服药依从性的测量时,推荐选择两种或者两种以上的测量方法。Long-term therapy should be administrated for patients with schizophrenia and the medication adherence is very important for the prognosis and outcome in these patients. In this study, we screened the literatures from various databases in accordance with our search criteria. A total of 11 literatures with the results of reliability and validity regarding the measurement of schizophrenia medication adherence were enrolled in our analysis. Based on the measurements, they were classified into subjective methods and objective ones. The objective methods include blood plasma and urine concentrations, pharmacy records, pill counts and Medication Event Monitoring System. The subjective methods include Drug Att itude Inventory, Rating of Medication Influences Scale, Brief Evaluation of Medication Influences and Beliefs, the Brief Adherence Rating Scale,Medication Adherence Rating Scale, and Morisky scales. In general, single method for measuring medication adherence in patients with schizophrenia is limited. We recommend researchers to use2 or more methods when measuring the medication adherence in patients with schizophrenia.

关 键 词：精神分裂症 服药依从性 测量方法 

分 类 号：R749.3[医药卫生—神经病学与精神病学]