未分化多形性肉瘤MRI特征及Ki-67表达与预后相关性  

Prognostic correlation of MRI characteristics and Ki-67 expression in undifferentiated pleomorphic sarcoma

作　　者：张九龙[1] 熊祚刚 张峰[2] 冯冰锦 汤光宇[1] 

机构地区：[1]安徽医科大学上海临床学院上海市第十人民医院放射科,上海200072 [2]同济大学附属第十人民医院放射科 [3]同济大学附属第十人民医院病理科

出　　处：《实用放射学杂志》2016年第3期396-399,共4页Journal of Practical Radiology

基　　金：国家自然科学基金面上项目（81371517）.

摘　　要：目的探讨未分化多形性肉瘤（UPS）的MRI特征及Ki-67表达与预后相关性。方法回顾性分析经手术病理证实的34例UPS MRI表现及临床病理资料，平均随访3年，按局部有无复发分为未复发组（15例）和复发组（19例），并分析2组患者年龄、肿瘤大小、位置、MRI特征（病灶边界、出血、坏死囊变、假包膜和瘤周特点）及Ki-67表达。结果2组肿瘤大小（P=0．002）、位置（P=0．025）、假包膜（P=0.025）、瘤周侵犯（p=0．008）及Ki-67表达（P=0．000）与肿瘤局部复发存在统计学相关性。结论术前MRI可观察UPS的特征、邻近组织关系及局部侵袭范围，有助于临床诊断及制订合适的手术方案。Objective To investigate the MRI features and Ki-67 expression and correlation with prognosis in undifferentiated pleomorphic sarcoma （UPS）. Methods MRI and clinicopathological data of 34 cases with UPS proved by operation and pathology were analyzed retrospectively（with an average follow-up of 3 years）. According to the presence of local recurrence, the data were divided into two groups：no recurrence group （15 cases） and recurrence group（ 19 cases）. Two groups were analyzed according to age, tumor size, location, MRI features （lesions margin,hemorrhage,necrosis,pseudocapsule and perilesional characteristics） and expression of Ki-67. Results The results showed that two groups tumor＇ s size （ P = 0. 002 ）, location （ P ： 0. 025 ）, pseudocapsule （ P ： 0. 025 ）, peritumoral tissue inva- sion （P= 0. 008）and expression of Ki-67 （P = 0. 000 ） were of statistical correlation with tumor local recurrence. Conclusion Preoper- ative MRI can observe the characteristics of undifferentiated pleomorphic sarcoma,the relationship with the adjacent tissue and local invasive scope,which will be helpful for clinical diagnosis and decision of surgical plan.

关 键 词：未分化多形性肉瘤 细胞核增殖抗原 磁共振成像 

分 类 号：R738.6[医药卫生—肿瘤] R445.2[医药卫生—临床医学]