Survivin和PDCD5在黏液表皮样癌组织中的表达及临床意义  

Expression of survivin and programmed cell death 5 in mucoepidermoid carcinoma and their clinical significance

作　　者：曲贝贝[1] 左金华[1] 朱玉红[2] 王丽芳[1] 

机构地区：[1]滨州医学院附属医院口腔颌面外科,256603 [2]滨州医学院附属医院病理科,256603

出　　处：《实用口腔医学杂志》2016年第2期225-229,共5页Journal of Practical Stomatology

基　　金：山东省医药卫生科技发展计划基金(编号:2011HW-004)

摘　　要：目的:探讨存活素(Survivin)和细胞程序性死亡因子5(PDCD5)在黏液表皮样癌组织中的表达及临床意义。方法:采用免疫组化Elivision二步法检测20例正常腮腺组织(A组)、40例多形性腺瘤(B组)及45例黏液表皮样癌(C组)组织中Survivin和PDCD5蛋白的表达情况。结果:(1)Survivin在A、B、C组中表达阳性率分别为10%、27.5%、55.6%(χ2=14.556,P<0.01),PDCD表达阳性率分别为85%、65%、33.3%(χ2=17.439,P<0.01);(2)Survivin和PDCD5的表达与肿瘤的分化程度、有无淋巴结转移及TNM分期有关(P<0.05);(3)Survivin和PDCD5在黏液表皮样癌中的表达呈负相关(χ2=4.500,P=0.034,γs=-0.316)。结论:Survivin高表达,PDCD5低表达在在黏液表皮样癌发生发展中可能发挥作用。Objective： To investigate the expression of Survivin and programmed cell death 5（ PDCD5） protein in mucoepidermoid carcinoma（ MEC）. Methods： Survivin and PDCD5 were detected by immunohistochemical staining in 20 cases of normal parotid tissue（ group A）,40 cases of pleomorphic adenoma（ group B） and 45 cases of MEC tissues（ group C）. Results： The positive expression ratio of Survivin in group A,B and C was 10. 0%,27. 5% and 55. 6% respectively（ χ2= 14. 556,P 〈0. 01）,while that of PDCD5 was 85%,65% and 33. 3% respectively（ χ2= 17. 439,P 〈0. 01）. The expression of survivin or PDCD5 was related with differentiation,lymph node metastasis and TNM staging of MEC. Survivin and PDCD5 showed a negative correlation in MEC（ χ2=4. 500,P = 0. 034,γs=- 0. 316）. Conclusion： Survivin over-expression and PDCD5 down-expression may play a role in the development and progress of mucoepidermoid carcinoma.

关 键 词：黏液表皮样癌(MEC) 存活素 细胞程序性死亡因子5(PDCD5) 免疫组织化学 

分 类 号：R739.87[医药卫生—肿瘤]