早产儿视网膜病变自然退行者视功能发育研究  

Research on visual function of preterm infants with spontaneous regression retinopathy of prematurity

作　　者：杨晨皓[1] 

机构地区：[1]复旦大学附属儿科医院眼科,上海201102

出　　处：《中国眼耳鼻喉科杂志》2016年第2期107-110,共4页Chinese Journal of Ophthalmology and Otorhinolaryngology

摘　　要：目的了解早产儿视网膜病变(ROP)自然退行者远期视功能的发育情况。方法前瞻性研究。观察ROP自然退行者(A组)与未发生ROP早产儿(B组)的视功能发育情况。分别在12、24和36月龄时进行3次随访,检查内容包括视力、屈光、眼底、眼位等。结果 A组共46例,男性25例、女性21例;孕周为(29.27±2.56)周;出生体重为(1 343.86±368.28)g;41例完成随访,失访率为10.9%。B组共48例,男性28例、女性20例;孕周为(30.40±2.75)周;出生体重为(1 432.61±347.13)g;40例完成随访,失访率为16.7%。2组失访率差异无统计学意义(P=0.607)。随访末,A组视力为0.58±0.17,B组视力为0.62±0.19,视力发育差异没有统计学意义(P=0.392);A组屈光状态中近视的发病率为14.6%,明显高于B组的5.0%,差异有统计学意义(P=0.04);A组斜视发病率为14.6%,高于B组的5.0%,差异有统计学意义(P=0.04)。结论 ROP自然退行者近视和斜视的发病率高于未发生ROP的早产儿。应建立长期、合理的视功能随访体系,对于早期发现的异常屈光状态(近视及中、高度远视)和斜视,要尽早干预、治疗,预防其弱视的发生。Objective To investigate the visual function of preterm infants with the history of spontaneous regression retinopathy of prematurity（ ROP）. Methods This was a prospective study. The study consisted of 46 preterm infants with ROP which showed spontaneous regression（ group A） and 48 preterm infants without ROP（ group B）. All the subjects were followed up at age of 12,24 and 36 months. Visual function was evaluated with visual acuity,refractive status,fundus and eye movement. Results Forty one subjects（ 89. 1%） completed follow-up at age of 36 months in group A whereas 40（ 83. 3%） in group B（ P = 0. 607）. At the end of the follow-up,the visual acuity in group A was0. 58 ± 0. 17,which was lower than that in group B（ 0. 62 ± 0. 19）,but the difference was not statistically significant（ P =0. 392）. Both myopic and strabismus incidence were higher in group A than those in group B,with significant differences（ P = 0. 04）. Conclusions Though the visual outcomes was not different between the two groups,the preterm infants with the history of spontaneous regression had high incidences of myopia and strabismus.

关 键 词：早产儿视网膜病变 自然退行 视功能 近视 斜视 

分 类 号：R774.1[医药卫生—眼科]