依达拉奉对脑梗死大鼠神经保护作用最佳治疗时间窗的探讨  

Golden Hour of Edaravone Neuroprotective Effect in Treatment of Cerebral Infarction in Rats

作　　者：张楠楠[1,2] 陈会生[2] 

机构地区：[1]大连医科大学研究生院,辽宁大连116027 [2]沈阳军区总医院神经内科,沈阳110840

出　　处：《解放军医药杂志》2016年第3期18-21,共4页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：辽宁省科技攻关计划(2013225089,2014225008)

摘　　要：目的采用大鼠大脑中动脉梗塞(MCAO)模型,探讨依达拉奉治疗急性脑梗死的最佳治疗时间窗。方法将MCAO模型大鼠随机分为A、B、C、D和E组(n=10)。A、B、C、D组分别于造模后0.5 h、1 h、1.5 h、2 h通过尾静脉给予3 mg/kg的依达拉奉,E组于造模后给予等量的生理盐水。于梗死后24 h进行神经功能缺损评分,并测量脑梗死体积。结果 A、B、C组神经功能缺损评分和脑梗死体积均低于E组(P<0.05,P<0.01),其中B组与E组比较差异更显著(P<0.01),B组低于A、C、D组(P<0.05,P<0.01),B组与D组比较差异更显著(P<0.01)。结论对大鼠MCAO模型,依达拉奉具有神经保护作用,且其神经保护作用有治疗时间窗。Objective To investigate the golden hour of Edaravone neuroprotective effect in treatment of rats with acute cerebral infarction using middle cerebral artery occlusion（ MCAO） models. Methods A total of 50 MCAO rat models were randomly divided into group A,B,C,D and E（ n = 10 in each group）. Group A,B,C and D were respectively injected with 3 mg / kg Edaravone via caudal vein infusion at 0. 5 h,1 h,1. 5 h and 2 h after models establishment,while the control group received the same volume of physiological saline after models establishment. The neurologic impairment scores were detected at 24 h after infarct,and the infarct volumes were also measured. Results The values of neurologic impairment scores and infarct volumes in group A,B and C were significantly lower than those in group E respectively（ P〈0. 05,P〈0. 01）,and the differences between group B and E were more significant（ P〈0. 01）,and the values in group B were lower than those in group A,C and D respectively（ P〈0. 05,P〈0. 01）,and the differences between group B and D were more significant（ P〈0. 01）. Conclusion Edaravone has neuroprotective effect in MCAO rats,and the effect has the golden hour.

关 键 词：大鼠 Sprague-Dawley 梗死 大脑中动脉 依达拉奉 神经保护药 治疗时间窗 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]