祛风安脑口服液质量标准研究  

Quality control of Qu Feng An Nao oral liquid

作　　者：蒋霞[1] 黄银妹[2] 王小洁[2] 兰丽华[2] 李梅[1] 

机构地区：[1]广西医科大学第一附属医院药学部,广西南宁530021 [2]广西医科大学药学院,广西南宁530021

出　　处：《中国民族民间医药》2016年第6期19-22,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：广西卫生厅中医药科技专项课题(GZYZ 1116)

摘　　要：目的：建立祛风安脑口服液定性、定量分析方法。方法：采用TLC对麻黄、黄芩、防风、川芎进行定性鉴别;采用HPLC测定阿魏酸含量,色谱条件：以Inertsil ODS-3（250mm×4.6nm,5μm）为色谱柱,甲醇-1%冰醋酸（30∶70）为流动相,检测波长为321nm,柱温为25℃。结果：薄层色谱斑点清晰,阴性对照无干扰;阿魏酸在1.824~10.940μg线性关系良好（r=0.9998）,平均回收率为100.51%,RSD=1.94%。结论：本方法简便易行、结果准确,可作为该产品质量控制的方法。Objective To establish Qu Feng An Nao oral liquid qualitative analysis method. Methods Using TLC to ephedra herb,radix scutellariae,radixsileris and rhizoma chuanxiong for qualitative identification,Preparation of ferulaic acid content is determined by HPLC,Inertsil ODS- 3（ 250 mm × 4. 6nm,5μm） chromatographic column was used. The mobile phase consisted of methanol and 1%Acetic acid（ 30∶ 70）; The ultraviolet wavelength was set at 321 nm,the colum temperature at 25℃. Results The thin layer plate by TLC spots were clear,Negative control without interference. Ferulaic acid showed a good linear relationship at a range of 1. 824- 10. 940μg（ r =0. 9998）,the average recovery rate was 100. 51%,RSD was 1. 94%. Conclusions The analysis method is simple feasible and the result is accurate; it can be used for quality control of Qu Feng An Nao oral liquid.

关 键 词：祛风安脑口服液 阿魏酸 HPLC TLC 

分 类 号：R286[医药卫生—中药学]