Recent advances and future directions in preclinical research of argininevasopressin(AVP) receptor blocker conivaptan in the context of stroke  

作　　者：Emil Zeynalov Susan M.Jones 

机构地区：[1]Swedish Medical Center,Neurotrauma Research Department Englewood

出　　处：《Neural Regeneration Research》2016年第3期392-393,共2页中国神经再生研究（英文版）

基　　金：Funding provided by the Swedish Medical Center to J.Paul Elliott,MD.Author Contributions:EZ-writing of the manuscript,SMJ-writing of the manuscript

摘　　要：Stroke is a major cause of mortality and permanent disability.The onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blood-brain barrier（BBB）,brain infarct and permanent tissue damage.Brain edema develops due to accumulation of water in intracellular and extracellular compartments of the brain,Stroke is a major cause of mortality and permanent disability.The onset of stroke is followed by life-threatening pathophysiological responses including brain edema,elevation of intracranial pressure,disruption of blood-brain barrier（BBB）,brain infarct and permanent tissue damage.Brain edema develops due to accumulation of water in intracellular and extracellular compartments of the brain,

关 键 词：edema permanent disability intracranial elevation blocker infarct disruption advances mortality 

分 类 号：R743.3[医药卫生—神经病学与精神病学]