阿托伐他汀对非乙醇性脂肪性肝病细胞因子的影响  

EFFECT OF ATORVASTATIN ON NON-ALCOHOLIC FATTY LIVER DISEASE CYTOKINES

作　　者：田新涛[1] 周秀梅[1] 顾华丽[1] 马承泰[1] 徐万群[1] 

机构地区：[1]青岛大学附属医院东区急诊科,山东青岛266071

出　　处：《青岛大学医学院学报》2016年第1期75-77,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市科技局基金项目(2012-1-3-2-(11)-nsh)

摘　　要：目的探讨非乙醇性脂肪肝（NAFLD）病人服用阿托伐他汀后肝功能酶学指标与血脂及细胞因子瘦素、脂联素、抵抗素、胰岛素样生长因子-1（IGF-1）的变化。方法 2011—2013年,选取我院门诊及住院的NAFLD病人100例（无其他并发症）,同时选取正常人100例作为对照组。NAFLD病人口服阿托伐他汀10mg,每天1次,疗程24周。所有病人治疗前及治疗后检测血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）的水平及谷丙转氨酶（ALT）、谷草转氨酶（AST）、谷氨酰转肽酶（γ-GT）及血清脂肪细胞因子瘦素、脂联素、抵抗素、IGF-1水平。结果治疗前NAFLD病人TC、TG、LDL、ALT、AST、γ-GT、瘦素、抵抗素水平明显高于对照组,而HDL、脂联素、IGF-1明显低于对照组,差异均有显著性（t=2.021～3.352,P〈0.05）。应用阿托伐他汀24周后,NAFLD病人TC、LDL、HDL明显好转,与对照组比较差异无显著性（P〉0.05）,但TG、ALT、AST差异有显著性（t=1.986～2.864,P〈0.05）。结论阿托伐他汀治疗NAFLD病人后主要肝功能、血脂指标及细胞因子瘦素、抵抗素、IGF-1水平明显好转,阿托伐他汀治疗NAFLD病人安全、有效。Objective To explore the changes of enzymatic indicators of liver function and blood lipid and cytokine leptin, adiponectin, resistin, insulin-like growth factor-1 in non-alcoholic fatty liver disease （NAFLD） patients after taking atorvastatin. Methods From 2011 to 2013,100 NAFLD patients, inpatients and outpatients, without other complications, were selected, and 100 healthy individuals served as controls. Oral atorvastatin 10 rag, was given to the patients, once a day for 24 weeks. Serum TC, TG, LDL, HDL, liver function, and adipokines leptin, adiponectin, resistin, insulin-like growth factor-1 levels, before and after treatment, were detected. Results Before treatment, the levels of TC, TG, LDL, AST, GGT, leptin, and resistin in the pa- tients were significantly higher than that in the control group, and HDL, adiponectin, insulin-like growth factor-1 were significant- ly lower （t = 2.021 - 3.352, P 〈0.05）. After 24 weeks of atorvastatin therapy, TC, LDL, and HDL in the patients significantly im- proved, no significant difference was noted versus the control group （P〉0.05）, but the differences in TG, ALT and AST were significant （t=l.986-2.864,P〈0.05）. Conclusion After atorvastatin treatment, the main liver function, levels of blood fat, cytokine leptin, resistin, and IGF-1 in the NAFLD patients markedly improved, indicating that atorvastatin is safe and effective for patients with FAFLD.

关 键 词：脂肪肝 瘦素 脂联素 抵抗素 胰岛素样生长因子Ⅰ 

分 类 号：R575.5[医药卫生—消化系统]