运用固本攻毒法治疗晚期胃癌90例  

Treatment of advanced gastric cancer using Guben Gongdu therapy:Analysis of 90 cases

作　　者：张新峰 乔翠霞[2] 程旭锋[3] 王怀璋 刘琦[4] 

机构地区：[1]郑州大学附属肿瘤医院中西医科,河南省郑州市450008 [2]河南省中医药研究院附属医院肿瘤科,河南省郑州市450003 [3]河南中医学院一附院乳腺科,河南省郑州市450000 [4]河南中医学院科研科,河南省郑州市450000

出　　处：《世界华人消化杂志》2016年第7期1087-1091,共5页World Chinese Journal of Digestology

基　　金：河南省医学科技攻关计划基金资助项目;No.201304099~~

摘　　要：目的:评价运用固本攻毒法联合替吉奥+顺铂方案化疗治疗晚期胃癌的近期疗效及安全性.方法:随机纳入符合试验标准的胃癌患者90例.对照组给予替吉奥+顺铂方案:替吉奥25mg/m^2,bid,po,d1-21;顺铂75 mg/m^2静脉滴注,d1;28 d/周期.治疗组行替吉奥+顺铂方案化疗联合固本攻毒法治疗;两组均在第二周期完成后评价两组患者近期疗效评价及不良反应发生率改善情况.结果:(1)近期疗效方面:对照组患者部分缓解6例(13.33%),稳定10例(22.22%),进展29例(64.44%),总体疾病控制率(disease control rate,DCR)35.56%;治疗组患者部分缓解9例(20.00%),稳定17例(22.22%),进展19例(42.22%),DCR为57.78%;两组近期临床疗效差异有统计学意义(P<0.05);(2)安全性方面:与对照组比较,治疗组血常规异常、恶心和呕吐的发生率明显降低(P<0.05).结论:运用固本攻毒法联合替吉奥+顺铂方案治疗晚期胃癌,近期疗效增加,化疗不良反应发生率降低,从而达到增效减毒之目的.AIM：To evaluate the short-term curative effect and security of Guben Gongdu therapy combined with S-1 ＋ cisplatin（ECX） in patients with gastric cancer（GC）.METHODS：This study included 90 patients with gastric cancer who were randomly divided into a treatment group and a control group.The control group received the ECX regimen alone：S-125 mg/m^2 orally,2/ d,d1-21;cisplatin 75 mg/ m^2 intravenous infusion,d1;28 d/ cycle.The treatment group received ECX chemotherapy combined with Guben Gongdu therapy.The incidence of adverse reactions was evaluated after the recent completion of the second cycle.RESULTS：In the control group,partial response（PR） was achieved in 6（13.33%）cases,stable disease（SD） was achieved in10（22.22%） cases,29（64.44%） patients had progressive disease（PD）,and the overall disease control rate was 35.56%.In the treatment group,PR was achieved in 9（20.00%）cases,SD was achieved in 17（37.78%） cases,19（42.22%） patients had PD,and the overall disease control rate was 57.78%.There was a significant difference in the short-term curative effect between the two groups（P 0.05）Compared to the control group,the rates of the abnormal routine blood tests,nausea and vomiting in the treatment group were significantly decreased（P 0.05）.CONCLUSION：Guben Gongdu therapy can improve the short-term curative effect and the incidence of side effects of chemotherapy in patients with gastric cancer.

关 键 词：胃癌 替吉奥+顺铂方案 固本攻毒法 

分 类 号：R735.2[医药卫生—肿瘤]