幽门螺杆菌感染与糖尿病  

Helicobacter pylori infection and diabetes mellitus

作　　者：宋淑然[1] 赵丽梅[2] 赵宝华[3] 

机构地区：[1]河北医科大学第二医院检验科,河北省石家庄市050000 [2]河北医科大学第二医院消化内科,河北省石家庄市050000 [3]河北师范大学生命科学学院,河北省石家庄市050024

出　　处：《世界华人消化杂志》2016年第8期1220-1226,共7页World Chinese Journal of Digestology

摘　　要：糖尿病患者幽门螺杆菌(Helicobacter pylori,H.pylori)感染率明显增加,H.pylori感染作为一个独立因素可促使胰岛素抵抗.糖尿病患者中的H.pylori根除率较正常人为低,合并H.pylori感染的糖尿病患者血糖波动范围增大,血糖不易被控制,治疗效果不佳,而根除H.pylori后有助于改善糖尿病的进展.H.pylori感染与糖尿病并发症(如糖尿病肾病、动脉粥样硬化、胃轻瘫等)的发生也有一定关系.H.pylori感染影响糖尿病的机制可能与系统性炎症反应、血管内皮损伤和激素水平改变(如瘦素和胃饥饿素)等因素有关.The rate of Helicobacter pylori （H. pylori） infection increases significantly in patients with diabetes mellitus. H. pylori infection as an independent factor can promote insulin resistance. H. pylori eradication rate is much lower in diabetic patients than in normal controls. Blood glucose levels tend to fluctuate more widely, and is not easy to be controlled in diabetic patients with H. pylori infection. Eradication of H. pylori can help to improve diabetic progression. H. pylori infection is related to the occurrence of diabetic complications, such as diabetic nephropathy, atherosclerosis, and gastroparesis. The mechanism of H. pylori infection affecting diabetes mellitus may be related to systemic inflammatory response, vascular endothelial damage and changes of hormone levels such as leptin and ghrelin.

关 键 词：幽门螺杆菌 糖尿病 高血糖 胰岛素抵抗 

分 类 号：R57[医药卫生—消化系统] R587.2[医药卫生—内科学] R446[医药卫生—临床医学]