Breast cancer-associated fibroblasts： their roles in tumor nitiation, progression and clinical applications  

作　　者：Aixiu Qiao Feng Gu Xiaojing Guo Xinmin Zhang Li Fu 

机构地区：[1]Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy of the Ministry of Education Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin 300060, China [2]Department of Pathology, Shanxi Medical University, Taiyuan 030001, China [3]Department of Pathology, Cooper University Hospital & Cooper Medical School of Rowan University, One Cooper Plaza, Camden, NJ 08103, USA

出　　处：《Frontiers of Medicine》2016年第1期33-40,共8页医学前沿（英文版）

基　　金：We apologize to those authors whose work was not cited because of space restrictions. This work was supported by a grant from the National Natural Science Foundation of China （No. 30930038）.

摘　　要：Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated libroblasts （CAFs）, the most abundant cells in tumor stroma, secrete various active biomolecules, including extraceHular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated libroblasts （CAFs）, the most abundant cells in tumor stroma, secrete various active biomolecules, including extraceHular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.

关 键 词：cancer-associated fibroblast breast cancer PROGRESSION PROGNOSIS 

分 类 号：Q516[生物学—生物化学] S858.315.3[农业科学—临床兽医学]