纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展  

Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma

作　　者：陈自强[1] 张玮[2] 李玉平[2] 王晓宇[3] 

机构地区：[1]第二军医大学附属长海医院骨科,上海200433 [2]同济大学附属上海市肺科医院药剂科,上海200433 [3]第二军医大学附属长海医院药学部,上海200433

出　　处：《药学实践杂志》2016年第2期103-105,共3页Journal of Pharmaceutical Practice

摘　　要：多药耐药是肿瘤化疗中的重要难题,多药耐药的机制复杂,目前尚无有效的治疗策略。纳米载药系统具有靶向性、载药种类多样等优点,近年来成为对抗肿瘤多药耐药的递药载体的重要研究方向。对肿瘤抑制的不同机制进行讨论,并对纳米载药系统逆转骨肉瘤多药耐药的研究进展进行综述。Multidrug resistance（MDR）of tumor cell is the major problem for chemotherapy.However,there is no effective strategy to overcome MDR due to the complicated mechanism.The nano-sized drug delivery system could target to the tumor cell.Moreover,it could delivery different kinds of drugs.Therefore,the nano-sized drug delivery system has become a promising approach to reverse MDR.The nano-sized drug delivery system which is applied to treat the MDR of tumor（osteosarcoma）was summarized and the reverse mechanism was discussed.

关 键 词：肿瘤 骨肉瘤 多药耐药 纳米载药系统 

分 类 号：R738.9[医药卫生—肿瘤] R94[医药卫生—临床医学]