眩晕宁胶囊对痰浊中阻型椎-基底动脉供血不足大鼠ANP、Glu的影响  

The Influence of Xuan Yun Ning Capsule on ANP and Glu Levels of Rats with Wertebral Basilar Artery Insufficiency of Phlegm Stagnation Type

作　　者：张婷[1] 白黎明[1] 杨秀清[1] 

机构地区：[1]陕西中医药大学,陕西咸阳712046

出　　处：《陕西中医学院学报》2016年第2期82-84,共3页Journal of Shaanxi College of Traditional Chinese Medicine

摘　　要：目的考察眩晕宁胶囊对痰浊中阻型椎-基底动脉供血不足大鼠血浆心钠素和脑组织谷氨酸的影响。方法大鼠随机分为假手术组、模型组、西比灵组、眩晕宁胶囊大、中、小剂量组,除假手术组外,其余各组大鼠基础饲料加用脂肪乳喂养及单侧椎动脉不全结扎法制作痰浊中阻型椎-基底动脉供血不足模型。造模成功后,各组给予相应的药物治疗14 d,观察大鼠行为学、平衡性、血浆ANP和脑组织中Glu的含量。结果眩晕宁胶囊能改善大鼠的行为学症状,与模型对照组相比,大、中剂量组血浆ANP含量明显升高,脑组织Glu含量均明显降低。结论眩晕宁胶囊剂具有脑保护作用,可能与提高血浆中ANP的水平,降低脑组织中的Glu含量有关。Objective： To investigate the Influence of Xuan Yun Ning Capsule on ANP and Glu levels of Rats with vertebral basilar artery insufficiency of phlegm stagnation type. Methods： Rats were randomly divided into sham operation group,model group,Sibeline group,Xuan Yun Ning capsule of high,medium and small dose group,except the sham operation group,rats in other groups were were fed with fat emulsion and Incomplete ligation of unilateral vertebral artery to prepare the vertebral basilar artery insufficiency of phlegm stagnation type rats. After successful modeling,the rats were treated with 14 d,and the content of Glu in the rat＇s behavior,balance,plasma ANP and brain tissue were observed.Results： Xuan Yun Ning Capsule can improve the behavioral symptoms of rats,compared with the model group,the plasma ANP levels in large and middle dose group were significantly increased,and the content of Glu in brain tissue was significantly decreased. Conclusion： It is possible to improve the level of ANP in plasma and decrease the content of Glu in brain tissue,which may be related to improving the level of plasma.

关 键 词：眩晕宁胶囊 椎基底动脉供血不足 心钠素 谷氨酸 

分 类 号：R743.31[医药卫生—神经病学与精神病学]