CD4^+CD25^+Treg与肺癌的发生发展  

CD4^+CD25^+Treg cells with the initiation,progression and metastasis of lung cancer

作　　者：王晓银[1] 王金岩[1] 

机构地区：[1]中国医科大学基础医学院免疫学教研室,辽宁沈阳110122

出　　处：《解剖科学进展》2016年第2期214-219,221,共7页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81272326)

摘　　要：机体免疫系统具有免疫监视功能及时识别及清除突变细胞防止肿瘤的发生,免疫监视功能下降可导致肿瘤的免疫逃逸。CD4+C D25+调节性T细胞是具有免疫负调节作用的T细胞亚群,在维持免疫耐受中起重要作用。通过检测FoxP 3和CD127可以发现CD4^+C D25^+调节性T细胞与肺癌的发生发展密切相关。Treg通过表达CTLA-4、GITR和PD-1等分子,分泌TNF-β、IL-6、IL-10和IL-17等细胞因子及抑制CD4^+/CD8^+T细胞、DC、NK细胞等细胞的产生和功能的发挥等促进肿瘤的免疫逃逸和肿瘤的发生发展。Treg和肿瘤微环境介导的血管新生、肿瘤基质破坏和肿瘤细胞与血管内皮细胞的相互作用促进了肿瘤的侵袭和迁移。Immune system has the ability of immunosurveillance and can recognize and clear the mutation cells to prevent the initiation of tumor, the decreased immunosurveillance resulted in the immuno-escape of tumor. CD4^＋CD25^＋Treg cells belong to the subgroup of T cells, have negative immune regulation and play an important role in maintaining immunotolerance, with a close relationship between lung cancer and CD4^＋CD25^＋Treg cells by detecting FoxP3 and CD127. CD4^＋CD25^＋Tregs promote the immuno-escape, initiation and prognosis of lung cancer by expressing CTLA-4, GITR and PD-1 and secreting TNF-β, IL-6, IL-10 and IL-17 and inhibiting the generation and function of CD4^＋/CD8^T cells, DC and NK cells. Tregs and tumor microenvironment can promote tumor metastasis by angiogenesis, tumor stroma destruction and the interact function of tumor cells and vascular endothelial cells.

关 键 词：CD4^+CD25^+TREG CD4^+CD25^+调节性T细胞 生发 肺癌 机体免疫系统 肿瘤微环境 CD8^+T细胞 CTLA-4 

分 类 号：R734.2[医药卫生—肿瘤]