Th17细胞与结直肠癌  

Th17 cells and colorectal cancer

作　　者：周倩[1] 金弢[2] 连晓媛[2] 张治针[3] 

机构地区：[1]安徽中医药大学药学院,合肥230038 [2]浙江大学药学院,杭州310058 [3]浙江大学海洋学院,杭州310058

出　　处：《免疫学杂志》2016年第4期360-364,共5页Immunological Journal

摘　　要：正常情况下,肠道内辅助性T细胞17(Th17)在维持肠内免疫稳态和抵抗外界病原微生物侵入方面起着重要的作用。然而近来研究发现Th17细胞异常分化、激活、增殖及其分泌的细胞因子(IL-17、IL-22、IL-21、IL-26)是导致结直肠癌发生发展的重要因素。故本文着重对Th17细胞及其分泌的细胞因子在结直肠癌发生发展中所起的作用进行综述并总结了其潜在的机制,为结直肠癌的防治提供新思路。Under normal condition, T helper 17（Th17） cells play an important role in keeping intestinalimmune homeostasis and resisting to external pathogenic microorganisms invasion. However, recent studies showthat Th17 cells＇ abnormal differentiation and activation and their secreted cytokines（IL-17, IL-22, IL-21, IL-26）have an important role in the development of colorectal cancer. This article focuses on reviewing the role of Th17 cells and their secreted cytokines in the development and advance of colorectal cancer, and summarizes theirpotential mechanism, which will bring some new ideas for the prevention and treatment of colorectal cancer.

关 键 词：TH17细胞 细胞因子 结直肠癌 

分 类 号：R735.34[医药卫生—肿瘤]