缺血性脑卒中急性期超敏C-反应蛋白水平变化与进展性卒中的相关性  

The correlation study between the level of high-sensitivity C-reactive protein in acute phase of ischemic stroke and progressive stroke

作　　者：姚涛[1] 任明山[1] 李淮玉[1] 

机构地区：[1]安徽医科大学附属省立医院神经内科,合肥市230001

出　　处：《实用医学杂志》2016年第5期735-738,共4页The Journal of Practical Medicine

基　　金：安徽省医学科研课题(编号:13zc016)

摘　　要：目的：探讨缺血性脑卒中（IS）急性期超敏C-反应蛋白（Hs-CRP）水平变化与进展性卒中的相关性。方法：收集急性IS患者101例,测定患者入院24 h内和发病48、72 h血清Hs-CRP含量,根据检测结果将患者分为Hs-CRP持续增长组（n=35）和非持续增长组（n=66）,完成两组患者的NIHSS评分,并通过多变量Logistic回归分析筛选出Hs-CRP持续增长可能的相关因素和进展性卒中发生的可能危险因素。结果：两组间Hs-CRP水平存在明显差异（P〈0.001）;Hs-CRP持续增长组进展性卒中发生率明显高于非持续增长组（χ^2=32.710,P〈0.001）;Logistic回归分析显示：（1）入院血糖、白细胞计数、甘油三酯水平、入院时NIHSS评分、24 h内Hs-CRP是Hs-CRP持续增长的独立相关因素;（2）Hs-CRP持续增长、入院NIHSS评分、糖尿病、肺部感染是进展性卒中发生的独立危险因素。结论：IS急性期Hs-CRP的持续增长是进展性卒中发生的独立预测因子。Objective To study the correlation of the level of high-sensitivity C-reactive protein（HsCRP） in the acute phase of ischemic stroke and progressive stroke. Methods 101 patients with acute ischemic stroke were collected. Serum Hs-CRP of all patients were measured at 24 hours after admission, the onset of 48 hours, the onset of 72 hours by latex enhanced immune turbidity method. According to their serum Hs-CRP levels, the patients were divided into the group of Hs-CRP sustained growth（n = 35） and the group of non HsCRP sustained growth（n = 66）. The NIHSS scores were assessed on two groups of patients, Logistic regression analysis was made to screen the related factors of Hs-CRP increase and the possible risky factors for progressive ischemic stroke. Results There was a significant difference of serum Hs-CRP level between the two groups（P 0.001）. The incidence of progressive stroke in the group of Hs-CRP sustained growth was significantly higher than that in the group of non Hs-CRP sustained growth（χ^2= 32.710, P 0.001）. Logistic regression analysis showed blood glucose, white blood cell count, triglyceride level and NIHSS scores at admission were associated with sustained growth of Hs-CRP and the factors that they included Hs-CRP sustained growth, admission NIHSS scores, diabetes mellitus and pulmonary infection were regarded as independent risk factors. Conclusion The sustained growth of Hs-CRP in the acute phase of ischemic stroke is an independent predictor of progressive stroke.

关 键 词：卒中 炎症 超敏C反应蛋白 进展性卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]