肠道菌群失调介导酒精性肝病发生发展的机制研究进展  

Alcoholic liver disease: gut microbiota and therapeutic perspectives

作　　者：臧月[1,2] 王生[1,2] 刘楠[1,2] 刘莉[1,2,3] 梅其炳[1,2,3] 

机构地区：[1]中国医药工业研究总院,上海200040 [2]上海医药工业研究院创新药物与制药工艺国家重点实验室,上海200437 [3]上海市生物物质成药性评价专业技术服务中心,上海200437

出　　处：《中国药理学通报》2016年第4期451-455,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No81370564)

摘　　要：酒精性肝病是一种慢性进行性疾病,严重影响患者健康。在一般情况下,肠道菌群处于动态平衡,维持肠道正常生理功能。当机体长期摄入酒精后,酒精及其代谢物通过引起肠道菌群数量改变、肠道通透性增加、细菌位移等方式造成肠道菌群紊乱,从而激活机体免疫应答,诱导肝脏产生促炎症因子,促进酒精性肝病发生发展。而补充益生菌或益生元调节肠道菌群紊乱可以有效的改善酒精性肝病的临床指征,提示调节肠道菌群失调将会成为临床治疗酒精性肝病行之有效的手段。该文就近年来国内外关于酒精摄入、肠道菌群失调、酒精性肝病之间的相互关系及调节菌群紊乱治疗酒精性肝病的进展进行概述,为菌群失调与酒精性肝病的研究和治疗提供理论参考。Alcoholic liver disease( ALD),a chronic progressive disease,threatens human health seriously. An increasing number of studies have shown that gut flora dysbiosis plays an important role in the development of ALD. Intestinal microbiota maintains a steady state under normal conditions,regulating gut flora normal physiological function. However,chronic alcohol consumption produces intestinal bacteria overgrowth and dysbiosis,including the alteration of the composition of intestinal microflora,the increment of gut permeability and bacterial translocation. Subsequently,the host immune is activated,promoting the production of inflammatory cytokines in liver,which plays a central role in the development of ALD. Notably,the supplement of prebiotics or probiotics reverses the intestinal flora disorder,ameliorating the clinical symptoms effectively in ALD patients. The evidence impies that the modulation of dysbiosis may be effective in the prevention and treatment of ALD. This review summarizes the research progress on the mechanism of the development of dysbiosis-mediated ALD,to provide a theoretical basis for the research on intestinal flora and ALD.

关 键 词：肠道菌群 酒精性肝病 细菌位移 促炎症因子 免疫应答 益生菌 

分 类 号：R-05[医药卫生] R322.45