Parkin相关疾病的研究进展  

Some diseases caused by Parkin

作　　者：姜懿纳 娄钰霞 张钊[2] 陈乃宏[1,2] 

机构地区：[1]湖南中医药大学药学院,长沙410208 [2]中国医学科学院北京协和医学院药物研究所,北京100050 [3]天津中医药大学,天津300193

出　　处：《中国药理学通报》2016年第4期455-458,共4页Chinese Pharmacological Bulletin

摘　　要：Parkin被日本学者证实与青少年型帕金森疾病相关后逐渐被越来越多的学者重视,并围绕其展开了大量研究。国内外诸多研究表明,Parkin的作用广泛,除帕金森疾病之外,其他相关疾病也依次被证实和Parkin及其与蛋白底物的相互作用相关,尤其在多种肿瘤以及白血病的发生和发展中具有重要作用。该文将就Parkin的最新研究展开综述。Since Parkin was confirmed by the Japanese scholar to be associated with juvenile Parkinson' s disease,it has come to be the focus of the scholars and a lot of researches have been made on it. Apart from Parkinson' s disease,many other diseases have also been proved to be associated with the role of Parkin and its interaction with protein substrates,especially in various kinds of cancer diseases and leukemia. This paper focuses on the latest research about Parkin and its development in tumor diseases and leukemia.

关 键 词：PARKIN 泛素 蛋白底物 帕金森 癌症 抑癌作用 白血病 

分 类 号：R-05[医药卫生] R341