肿瘤治疗新靶点TRAP1研究进展  

Research progress of a new oncotherapy target TRAP1

作　　者：沈培亮[1,2] 刘兆国[1,2] 孙丽华[1,2] 王旭[1,2] 沈颖[1,2] 吴红雁[1,2] 王爱云[1,2,3] 陆茵[1,2,3] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药药效与安全性评价重点实验室,江苏南京210023 [3]江苏省中医药防治肿瘤协同创新中心,江苏南京210023

出　　处：《中国药理学通报》2016年第4期459-463,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金项目资助(No81173174;81573859);江苏省自然科学基金(NoBK2012854);江苏省研究生创新基金(NoCXLX12_0587;KYZZ_0270);江苏省科技厅项目(NoBY2015008-02);江苏高校优秀科技创新团队计划;江苏高校品牌专业建设工程资助项目(NoPPZY2015A070);江苏高校中药学优势学科建设工程资助项目(PAPD)

摘　　要：肿瘤坏死因子受体相关蛋白1(tumor necrosis factor receptor-associated protein 1,TRAP1)是热休克蛋白90(Hsp90)家族的主要成员之一,其不仅能够抵御氧化应激所诱导的凋亡,同时在维持线粒体完整性及细胞内稳态方面也发挥着重要作用。研究发现,TRAP1的异常表达与多种肿瘤的发生、发展密切相关。进一步研究表明,TRAP1是肿瘤细胞内能量代谢重新编排的关键调控因素,干预其功能可导致肿瘤细胞的死亡,但却对正常细胞没有影响。这使得TRAP1作为治疗靶点,备受人们关注。该文对TRAP1蛋白的异常表达与肿瘤研究进展进行综述,探讨TRAP1蛋白调控肿瘤进程的相关分子机制,为临床的后续研究和治疗提供参考。Tumor necrosis factor receptor-associated protein 1( TRAP1),as one of the main members of the heat shock protein90 family,resists oxidative stress-induced apoptosis as well as predominantly maintains the integrity of mitochondria and cellular homeostasis. Abnormal expression of TRAP1 was herein closely related to the onset and progression of a wide variety of tumors. As a key regulatory factor mediating energy metabolism within tumor cells,TRAP1 may be able to kill them by interfering with such metabolism. More importantly,the abnormal expression of TRAP1 played a less important role in normal cells,allowing TRAP1 to be a particularly attractive target as it can be used in tumor treatment or interference. The relationship between abnormal expression of TRAP1 protein and tumor onset was reviewed. Besides, the mechanism by which disordered TRAP1 protein expression induced tumor formation was postulated,which may provide references for future research and clinical treatment.

关 键 词：TRAP1 AMPK 肿瘤 异常表达 分子机制 临床治疗 

分 类 号：R-05[医药卫生] R329.25