Notch信号通路在糖尿病并发症中的研究进展  

Research progress on Notch signaling pathway and diabetic complications

作　　者：张彬[1] 孟祥宝[1] 陈亚萍[2] 孙桂波[1] 孙晓波[1] 

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所,北京100193 [2]北京理工大学生命学院,北京100081

出　　处：《中国药理学通报》2016年第4期463-467,共5页Chinese Pharmacological Bulletin

基　　金：国家科技部"重大新药创制"科技重大专项资助项目(No2012ZX09501001-004);北京市科技计划课题(NoZ141100002114044)

摘　　要：Notch是一种广泛存在于脊椎动物和非脊椎动物中高度保守的信号转导通路,它通过介导细胞间的关联而调节细胞生理和病理过程,包括细胞的增殖、分化和凋亡。研究发现,Notch通路的异常与糖尿病及其并发症有密切的关系,该文对Notch信号通路的分子基础及其异常表达与糖尿病之间的关系进行综述,重点探讨Notch信号通路及其关键分子对糖尿病并发症及其机制的影响。Notch signaling,a highly conserved pathway,is widely found in invertebrates and vertebrates. By mediating cell communication,it can regulate many physiological and pathological processes in various kinds of cells,including cell proliferation,differentiation and apoptosis in multi-cellular organism. Accumulating evidence shows that abnormality in Notch signaling is highly related to diabetes mellitus and its complications. Accordingly,this paper reviews the molecular basis of Notch signaling and the relations between its abnormal expression and diabetes mellitus,and focuses on the impact of key elements in the Notch signaling pathway on diabetic complications as well as correlative mechanisms.

关 键 词：糖尿病 NOTCH 信号通路 视网膜 心肌病 并发症 

分 类 号：R-05[医药卫生] R329.24