2型糖尿病合并甲状腺癌的发生率及预后相关影响因素分析  

The Incidence and Prognostic Factors of Type 2 Diabetes Mellitus Patients with Thyroid Cancer

作　　者：罗德富[1] 李鸿[1] 

机构地区：[1]四川省都江堰市人民医院,611830

出　　处：《实用癌症杂志》2016年第4期601-603,共3页The Practical Journal of Cancer

摘　　要：目的探讨2型糖尿病合并甲状腺癌的发生率及预后的相关影响因素。方法以534例住院2型糖尿病患者为研究对象,回顾分析其空腹血糖、餐后2 h血糖、胰岛素(FINS)以及甲状腺彩超检查的结果,对2型糖尿病患者的甲状腺癌发生率及预后相关因素进行分析。结果 2型糖尿病患者甲状腺癌的发生率为19.7%,女性的发生率为12.4%,高于男性6.4%,且随年龄的增加甲状腺癌的发病率增加。单因素分析结果表明,影响2型糖尿病合并甲状腺癌患者3年生存率的主要相关因素为性别、年龄、病理类型、淋巴结转移、临床分期、病程和胰岛素依赖。多因素回归分析结果显示,病理类型、临床分期、病程、胰岛素抵抗是影响2型糖尿病合并甲状腺癌患者预后的独立因素(P<0.05)。结论2型糖尿病患者的甲状腺癌的患病率较高,病理类型、临床分期、病程、胰岛素抵抗可能是2型糖尿病患者甲状腺癌预后的独立影响因素。临床实践中,应及时对患者进行甲状腺癌筛查,早发现早治疗,以减少甲状腺癌的发生。Objective To explore the incidence and prognostic factors of type 2 diabetes patients with thyroid cancer. Methods 534 cases of hospitalized patients with type 2 diabetes were selected. Fasting blood glucose, blood glucose 2 hours after meal, FINS and thyroid ultrasonography were retrospectively analyzed,the incidence and prognosis factors of type 2 diabetes with thyroid cancer were analyzed. Results The onset of type 2 diabetes with thyroid cancer was 19.7% , the occurrence of female was 12.4%, higher than that of male,6.4%, and the incidence of thyroid cancer increased with age. Univariate analysis showed that influence factors of 3-year survival rate were gender, age, pathological type, lymph node metastasis, clinical stage, duration and in- sulin-dependent. Multiple regression analysis showed that pathological type, clinical stage, duration and insulin resistance were independent factors for type 2 diabetes and thyroid cancer prognosis （ P 〈 0.05 ）. Conclusion The prevalence of diabetes is higher in patients with thyroid cancer, histological type, clinical stage, duration, insulin resistance may be independent factors for prognosis of type 2 diabetes patients with thyroid cancer. In clinical practice ,patients should receive thyroid cancer screening, early de- tection and early treatment can reduce the incidence of thyroid cancer.

关 键 词：2型糖尿病 甲状腺癌 相关性 发生率 

分 类 号：R736.1[医药卫生—肿瘤]