ROC曲线确定急性脑梗死患者D-二聚体临界值诊断及意义  

The Diagnosis Cut-off Point of Acute Cerebral Infarction by D-dimer Content Using ROC Curve

作　　者：何秋贤[1] 李锦荣[1] 徐玉凤[1] 

机构地区：[1]佛山市顺德区第一人民医院检验科,广东佛山528300

出　　处：《黑龙江医学》2016年第3期206-207,共2页Heilongjiang Medical Journal

摘　　要：目的应用ROC曲线确定急性脑梗死患者D-二聚体定量临界值及诊断意义。方法依据急性脑梗死患者诊断标准收集佛山市顺德区第一人民医院患者D-二聚体定量检查标本100例,采用免疫比浊法检测D-二聚体含量并绘制ROC曲线,应用统计软件进行分析,确定诊断临界值。结果 D-二聚体用于急性脑梗死患者的诊断临界值为1.00μg/mL(灵敏度为89%,特异性为85%)。结论研究确定急性脑梗死患者D-二聚体诊断临界值,相对于试剂盒推荐诊断临界值(0.5μg/mL)具有更好的准确性,能够有效提高临床诊断效率,具有临床推广使用价值。Objective To determine the diagnosis cut-off point of acute cerebral infarction by D-dimer content using ROC curve and appraise its clinical significance.Methods 100 patients＇ specimens were collected according to the acute cerebral infarction diagnosis standard,using immunoturbidimetric methods to measure the D-dimer content,draw up the ROC curve,and determine the diagnosis cut-off point of acute cerebral infarction by statistical analysis.Results The D-dimer cut-off point of acute cerebral infarction clinical diagnosis was 1.00 μg/mL（ sensitivity was 89%,specificity was 85%）.Conclusion The cut-off point determined by this research possessed better accuracy compared to 0.5 μg/mL provided by the reagent box as the same diagnosis standards,effectively improve the efficiency of clinical diagnosis and could be worthy of clinical areas.

关 键 词：ROC曲线 D-二聚体 急性脑梗死 

分 类 号：R743.33[医药卫生—神经病学与精神病学]