APELIN/APJ系统：抗眼内新生血管的新靶点  

APELIN/APJ system ： a new target of anti intraocular neovascularization

作　　者：刘帅[1] 金海鹰[1] 

机构地区：[1]上海交通大学医学院附属新华医院眼科,200093

出　　处：《国际眼科纵览》2016年第1期1-6,共6页International Review of Ophthalmology

基　　金：国家自然科学基金项目（81100655）;上海市新兴前沿项目（SHDC12012104）

摘　　要：视网膜新生血管形成是增生性糖尿病视网膜病变、早产儿视网膜病变及缺血性视网膜中央静脉阻塞等视网膜疾病的共同并发症,是这些疾病致盲的主要原因.研究表明多种因子参与新生血管的形成,如血管内皮生长因子、碱性成纤维细胞生长因子等.APELIN是孤儿G蛋白藕连受体（orphan G-protein-coupled receptor,GPCR） APJ的内源性配体,广泛分布于各种组织,具有多种生物学功能.新近研究表明,APELIN在生理及病理性血管新生中具有重要作用,可能成为抗眼内新生血管的新靶点.Retinal neovascularization is a common complication of proliferative diabetic retinopathy （PDR）,retinopathy of prematurity （ROP） and ischemic central retinal vein occlusion and other retinal diseases,which is leading cause of blindness to these diseases.Studies have shown that multiple factors involve in the angiogenesis,such as vascular endothelial growth factor （VEGF）,basic fibroblast growth factor （bFGF）,etc.APELIN is an endogenous ligand for the G protein-coupled receptor of APJ,and widely distributes in various tissues,with a variety of biological functions.Recently,studies show that APELIN is a novel angiogenic factor,which has an important role in physiological and pathological angiogenesis,will provide a new target to anti-neovascularization.

关 键 词：视网膜 新生血管形成 

分 类 号：R775.9[医药卫生—眼科]