脂肪组织在急性淋巴细胞白血病耐药中的作用  

The role of adipose tissue-derived treatment in resistant acute lymphoblastic leukemia

作　　者：薛正彪 王淑芳[1] 李慧慧[1] 余莉[1] 

机构地区：[1]南昌大学第二附属医院血液内科,南昌330000

出　　处：《临床血液学杂志》2016年第2期259-261,共3页Journal of Clinical Hematology

基　　金：国家自然科学基金(No:81460030)

摘　　要：肥胖已成为影响我国成人和儿童健康的巨大挑战,我国35~64岁中年人群超重率已达38.8%,肥胖率20.2%。Ⅱ型糖尿病、心血管疾病、高血压、骨关节炎以及肿瘤均与肥胖密切相关。近年来研究表明,由肿瘤细胞、正常细胞、细胞内基质及相关信号分子等组成的肿瘤微环境在肿瘤的扩散、转移及耐药等方面发挥了重要作用。在实体肿瘤中,肿瘤细胞与成纤维细胞、巨噬细胞、淋巴细胞、内皮细胞以及脂肪细胞等相互作用,通过细胞间相互作用改变细胞所处微环境，使微环境中的肿瘤细胞更易获得营养物质、生长因子、能量支持及逃避免疫监视。Epidemiological studies have shown that there is a connection between obesity and the prognosis in pediatric acute lymphoblastic leukemia（ALL）.Compared with the body lean group,the incidence of minimal residual disease in the obese group is 2.50 to 2.75 times higher,and 5-year disease-free survival in the obese group is significantly shorter.Adipose tissue plays an active role in many types of tumor microenvironment.Recently,it has been discovered that adipose tissue plays a special role in the development,treatment and prognosis of ALL through a variety of ways.In addition,the biological field of adipose tissue has also made a breakthrough.This paper is a brief review that how the adipose tissue affect the curative effect,prognosis and resistant mechanism of the patients with ALL.

关 键 词：脂肪组织 肿瘤微环境 白血病 淋巴细胞 急性 肥胖症 耐药性 

分 类 号：R733.71[医药卫生—肿瘤]