青少年血尿酸水平与心血管代谢危险因子的相关性分析  

Association between serum uric acid level and cardiovascular metabolism risk factors in adolescents

作　　者：庄婧誉[1] 徐滨华[2] 段滨红[3] 崔岳崇 刘永昆[1] 陈素芬[1] 王瑞凤[1] 周勇[1] 孙彩虹[1] 夏薇[1] 王佳[1] 张慧颖[1] 马军[4] 王海俊[4] 

机构地区：[1]哈尔滨医科大学公共卫生学院儿少卫生与妇幼保健学教研室,黑龙江150081 [2]哈尔滨市第一医院内分泌二科 [3]黑龙江省医院内分泌科 [4]北京大学公共卫生学院儿童青少年卫生研究所

出　　处：《中国学校卫生》2016年第3期425-427,431,共4页Chinese Journal of School Health

基　　金：卫生行业科研专项基金项目(201202010)

摘　　要：目的了解青少年血尿酸水平与心血管代谢危险因子的相关性,为预防儿童高尿酸血症,降低心血管疾病的风险提供参考依据。方法以哈尔滨市城区1 640名10-18岁中小学生为研究对象,对其进行体格检查,并测定血尿酸（SUA）、三酰甘油（TG）、胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）等。结果高尿酸血症的检出率为23.0%（377/1 640）,男生为29.7%（242/816）,女生为16.4%（135/824）,男生检出率高于女生（χ-2=40.80,P〈0.05）。不同性别中小学生心血管代谢危险因子的患病率差异均有统计学意义,高血糖、低HDL-C以及超重或肥胖的患病率均为男生高于女生（χ-2值分别为10.101,2.829,24.602,P值均〈0.05）。FPG,TG,HDL-C,超重或肥胖以及血压异常组的血尿酸水平均高于其正常组（t值分别为4.003,7.422,5.369,13.340,5.753,P值均〈0.05）。血尿酸水平与心血管代谢危险因子收缩压（SBP）、舒张压（DBP）、FPG、TG、体质量指数（BMI）均呈正相关（r值分别为0.352,0.127,0.176,0.232,0.441,P值均〈0.05）,而与HDL-C呈负相关（r=-0.238,P〈0.05）。将研究对象按SUA水平四分位间距分成4组,随着血尿酸水平的增高,SBP,DBP,FPG,TG,BMI水平随之升高,而HDL-C水平随之降低（P值均〈0.05）。结论 10-18岁青少年血尿酸水平与心血管代谢危险因子存在密切相关性,防治高尿酸血症应从儿童青少年开始。Objective To understand association between the level of serum uric acid（ SUA） and the cardiovascular metabolism risk factors. Methods Totally 1 640 adolescents aged 10 to 18 years old were selected in Harbin. Physical examination was carried on and the level of SUA, TG, TC, HDL- C, LDL- C and FPG were analyzed. Results The detection rate of SUA was 23. 0%（ 377 /1 640） in general, with 29. 7%（ 242 /816） in boys and 16. 4%（ 135 /824） in girls（ χ2= 40. 80, P〈0. 05）.Gender differences were significant in cardiovascular metabolism risk factors, hyperglycemia, low-high density lipoprotein cholesterol, overweight or obesity, with boys higher than in girls（ χ2= 10. 101, 2. 829, 24. 602, P〈0. 05）. The levels of SUA were higher in groups with abnormal glucose, triglyceride, HDL- C, overweight or obesity and blood pressure than in groups with normal value（ t = 4. 003, 7. 422, 5. 369, 13. 340, 5. 753, P〈0. 05）. The relationship between SUA and the cardiovascular metabolism risk factors, such as SBP, DBP, FPG, TG and BMI were positively correlated（ r = 0. 352, 0. 127, 0. 176, 0. 232, 0. 441, P〈0. 05）. However, there were negative correlation between SUA and HDL- C（ r =- 0. 238, P〈0. 05）. The objects were divided into Q1- Q4 groups according to the level of SUA quartile, the values of SBP, DBP, FPG, TG, BMI increased and of HDL- C decreased, with increasing of the level of SUA（ P〈0. 05）. Conclusion There is significant relation between the level of SUA and the cardiovascular metabolism risk factors in adolescents aged 10 to 18, which indicates that prevention and treatment of SUA should start from adolescents.

关 键 词：尿酸 心血管疾病 危险因素 青少年 

分 类 号：R179[医药卫生—妇幼卫生保健] R195[医药卫生—公共卫生与预防医学]