注射用生长抑素治疗结直肠术后早期炎性肠梗阻的随机对照研究  

A randomized controlled trial of somatostatin for injection in EPISBO of colorectal surgery

作　　者：林国辉[1] 李燕萍[1] 张思宇[1] 

机构地区：[1]厦门大学附属第一医院普外科,福建厦门361003

出　　处：《中国生化药物杂志》2016年第2期68-69,72,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨结直肠术后早期炎性肠梗阻患者治疗中行注射用生长抑素的应用效果。方法 以2013年1月~2015年6月于厦门大学附属第一医院普外科治疗的68例结直肠术后早期炎性肠梗阻患者为研究对象,根据采取治疗方法的不同分为对照组与治疗组,每组34例。2组均给予常规治疗,治疗组在常规治疗的基础上增加注射用生长抑素治疗,比较2组临床症状改善情况,血清肌酸磷酸激酶、清蛋白及总蛋白水平与治愈时间。结果 治疗组肛门排气时间、肠鸣音恢复时间与腹胀消失时间均短于对照组（P〈0.05）,治疗组胃肠减压引流量少于对照组（P〈0.05）。治疗组治疗后血清肌酸磷酸激酶低于对照组（P〈0.05）。治疗后,2组间总蛋白与清蛋白比较差异无统计学意义。治疗组治愈时间为（10.4±3.8）d,明显短于对照组的（16.6±5.3）d（P〈0.05）。结论在常规治疗的基础上,对结直肠术后早期炎性肠梗阻患者增加注射用生长抑素治疗,可有效缓解腹胀,促进肠鸣音与肛门排气的恢复,使血清肌酸磷酸激酶升高,缩短治愈时间,对早期炎性肠梗阻具有较高治疗价值。Objective To explore application effects of somatostatin for injection in the treatment of patients with early postoperative inflammatory small bowel obstruction （EPISBO） of colorectal surgery. Methods Sixty-eight patients with EPISBO from January 2013 to June 2015 treated in the hospital were selected and divided into the control group and the treatment group with 34 patients in each group according to different treatment methods. Both groups of patients were subject to conventional treatment, the patients in the treatment group were added with somatostatin therapy on the basis of conventional treatment. The improvements of clinical symptoms, serum creatine phosphokinase, albumin, total protein level and healing time of patients in two groups were compared. Results The exsufflation time of anus, recovery time of borborygmus, disappearance time of abdominal distension and healing time of patients in treatment group were shorter than those indexes in control group （ P 〈 0. 05 ） . The drainage flow of gastrointestinal decompression of patients in treatment group was lower than that in control group （P 〈 0.05 ）. The serum creatine phosphokinase in treatment group was lower than that in control group （P 〈 0.05 ）. There were no significant differences in total protein and albumin post-treatment between two groups. The healing time in treatment group was shorter than that in control group [ （ 10.4 ±3.8 ） d vs. （ 16. 6 ± 5.3 ） d, P 〈 0. 05 ]. Conclusion On the basis of conventional treatment, the somatostatin could effectively reduce the bloating, facilitate the recovery of borborygmus and anus exsufflation, increase serum creatine phosphokinase and shorten the healing time in the treatment of patients with EPISBOof colorectal surgery.

关 键 词：肠梗阻 注射用生长抑素 应用价值 

分 类 号：R574.2[医药卫生—消化系统]