循环血肿瘤细胞为肿瘤精准治疗带来的机遇与挑战  

Circulating tumor cells for precision medicine in cancer

作　　者：谢思琪 罗以[2] 

机构地区：[1]南华大学研究生院协作医院湖南省肿瘤医院,长沙410013 [2]湖南省肿瘤医院特需/头颈内科,长沙410013

出　　处：《中国医师杂志》2016年第3期468-470,共3页Journal of Chinese Physician

基　　金：国家重点专科（肿瘤科）-以基因组为导向的肿瘤个体化医学研究中心课题项目.

摘　　要：下一代测序技术研究中,越来越多的证据证明了一个假说-肿瘤是一类以达尔文进化为特征的疾病.然而,医生往往不能根据肿瘤不同阶段的生物学特征做治疗决策,这也许是导致很多治疗手段最终失败的关键原因.循环血肿瘤细胞（CTCs）的检测被认为是一种“液体活检”技术,对CTCs进行动态监测,获取肿瘤不同阶段的进化信息,能为肿瘤的个体化治疗提供依据.Over the last two decades,we have seen many advances in the biological underpinnings of many kinds of cancers that have had a significant impact either directly or indirectly on the management and ultimately on the prognostic outcome of this disease.Next-generation sequencing studies have provided further evidence to support the notion4 that cancer is a disease characterized by Darwinian evolution.However,Ones often fail to obtain the information in different stages of the tumor before making treatment decision.This may be the major reason for treatment failures.Currently,circulating tumor cells （CTCs） is considered as a ＆quot; liquid biopsy＆quot;.By detecting CTCs at different stages of tumor and obtaining the biological characteristics of CTCs,ones can get information about tumor evolution at different stages.It might provide effective basis for individual therapy to tumors,and promote the accuracy of tumor treatment.

关 键 词：肿瘤循环细胞 肿瘤/治疗 综述 

分 类 号：R730.5[医药卫生—肿瘤]