普拉洛芬联合玻璃酸钠治疗干眼的临床疗效观察  

Clinical observation on effect of pranoprofen eye drops combined with sodium hyaluronate eye drops in dry eye

作　　者：刘雅琴[1] 李晶 具尔提.阿不都卡地尔 向阳[3] 钱一[1] 王建宏[1] 高亚明[1] 李芳[1] 艾尼瓦尔.阿布都克里木 张宏[1] 

机构地区：[1]新疆医科大学第一附属医院眼科,乌鲁木齐830054 [2]新疆乌鲁木齐市友谊医院眼科,乌鲁木齐830049 [3]新疆医科大学公共卫生学院流行病学教研室,乌鲁木齐830011

出　　处：《新疆医科大学学报》2016年第4期456-459,共4页Journal of Xinjiang Medical University

基　　金：乌鲁木齐市科学技术计划项目(Y131310003)

摘　　要：目的观察普拉洛芬滴眼液联合0.1%玻璃酸钠滴眼液治疗干眼患者的临床疗效。方法选择2014年7月—2015年6月就诊于新疆医科大学第一附属医院眼科门诊、符合纳入标准的干眼患者235例(280眼)。随机分为联合用药组(142眼)和单纯用药组(138眼),对联合用药组给予普拉洛芬滴眼液联合0.1%玻璃酸钠滴眼液治疗,单纯用药组给予0.1%玻璃酸钠滴眼液治疗,用药前和用药1个月后对纳入对象进行标准干眼症状评估(SPEED)问卷评分调查,并对两组患者的泪膜破裂时间(BUT)、角膜荧光素染色(FLS)、泪液分泌功能(Schirmer I试验)进行检查和比较。结果用药后两组患者自觉症状及临床症状均较用药前有所改善,联合用药组及单纯用药组治疗后标准干眼症状评估(SPEED)问卷评分差异有统计学意义(t=2.25,P=0.03),治疗后联合用药组较单纯用药组泪膜破裂时间(BUT)增加,差异有统计学意义(t=3.00,P=0.00),联合用药组治疗后较单纯用药组治疗后角膜荧光染色(FLS)改善更明显,差异有统计学意义(t=3.58,P=0.00),而两组干眼病人用药后泪液分泌功能(Schirmer I test)差异无统计学意义(t=0.87,P=0.16>0.05)。结论普拉洛芬滴眼液联合0.1%玻璃酸钠滴眼液治疗干眼较单独使用0.1%玻璃酸钠滴眼液治疗干眼的临床疗效好。Objetive To investigate the clinical efficacy of the dry eye treated by the pranoprofen eye drops combined with the 0.1% sodium hyaluronate eye drops.Methods A total of 235 dry eyes patients（280eyes）,from the ophthalmology clinic outpatient department in the First Affiliated Hospital of Xinjiang Medical University between July 2014 to June 2015,were randomly divided into combination group（142eyes）and simple group（138eyes）.All patients met the inclusion criteria.The combination group was treated by pranoprofen drops combined with 1%sodium hyaluronate eye drops,and the simple group treated by 1%sodium hyaluronate eye drops.The Standard Patient Evaluation of Eye Dryness（SPEED）questionnaire were carried out before and after medication.The tear film breakup time（BUT）,corneal fluorescence staining（FLS）score and Schirmer I test were performed in all patients.The results of the two groups were compared.Results After the medication,both the self-conscious symptom and clinical symptoms were better than those before the medication.The difference of Standard Patient Evaluation of Eye Dryness（SPEED）questionnaire between the combination group and the simple group had statistical significance after medication（t=2.25 P =0.03）,The BUT was longer in the combination group compared with the simple group after treatment（t=3.00 P =0.00）.The corneal fluorescence staining score was significantly lower in the combination group compared with the simple group after treatment（t=3.58 P =0.00）.In addition,The difference of Sehirmer I test score between the two groups has no statistical significance after medication（t=0.87 P =0.160,05）.Conclusion The combination of pranoprofen dry drops with 0.1% sodium hyaluronate eye drops had good effect on treatment to dry eye,which was better than the effect of pure 0.1% sodium hyaluronate eye drops.

关 键 词：干眼 普拉洛芬 玻璃酸钠 

分 类 号：R77[医药卫生—眼科]