Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers  

作　　者：SUN Weihong XING Lihong LIN Hong LENG Kailiang ZHAI Yuxiu LIU Xiaofang 

机构地区：[1]Yellow Sea Fishery Research Institute,Chinese Academy of Fishery Sciences [2]College of Food Science and Engineering,Ocean University of China

出　　处：《Journal of Ocean University of China》2016年第2期283-287,共5页中国海洋大学学报（英文版）

基　　金：supported by Program for Changjiang Scholars and Innovative Research Team in University (IRT1188)

摘　　要：In recent years,the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied.It was reported that all-trans astaxanthin might exist as three stereoisomers,and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products.However,the different biological effects of various all-trans stereoisomers still remain unclear.In the present study,we evaluated the bioactivity of three astaxanthin stereoisomers,(3S,3'S)-trans-,(3R,3'R)-transand meso-trans-astaxanthin,in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells(PECs) systems.After the treatment with three astaxanthin stereoisomers(20 μmol L-1),the lymphocyte proliferation capacity,neutral red phagocytosis of PECs and natural killer(NK) cell cytotoxic activity were comparatively assessed.The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation,phagocytic capacity of PECs,and cytotoxic activity of NK cells.Moreover,the(3S,3'S)-trans-astaxanthin exhibited a much higher response than others.In recent years, the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied. It was reported that all-trans astaxanthin might exist as three stereoisomers, and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products. However, the different biological effects of various all-trans stereoisomers still re- main unclear. In the present study, we evaluated the bioactivity of three astaxanthin stereoisomers, （3S,3 ＇S）-trans-, （3R,3 ＇R）-trans- and meso-trans-astaxanthin, in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells （PECs） systems. After the treatment with three astaxanthin stereoisomers （20 μmolL-1）, the lymphocyte proliferation capacity, neutral red phagocytosis of PECs and natural killer （NK） cell cytotoxic activity were comparatively assessed. The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation, phagocytic capacity of PECs, and cytotoxic activity of NK cells. Moreover, the （3S,3 ＇S）-trans-astaxanthin exhibited a much higher response than others.

关 键 词：all-trans-astaxanthin STEREOISOMER IMMUNITY 

分 类 号：S917.4[农业科学—水产科学]