肌圆锥内注射透明质酸对幼兔眼眶发育的影响  

Effects of injecting hyaluronic acid into muscle cone on orbital development of immature rabbits

作　　者：王娟 庞润晖 刘兆川[2] 李妍 张宏彬 史俊虎 李荣荣 白萍 

机构地区：[1]河北省眼科医院、河北省眼科学重点实验室、河北省眼病治疗中心,河北省邢台市054001 [2]中山大学中山眼科中心,广东省广州市528000

出　　处：《眼科新进展》2016年第4期331-333,共3页Recent Advances in Ophthalmology

摘　　要：目的观察幼兔肌圆锥内注射透明质酸刺激眼眶生长发育的程度及引起眼眶容积的变化。方法选取30只新西兰幼兔(1个月龄),随机分为3组,其中A组、B组各10只,均摘除左眼球,保留右眼,A组在术后7 d,左眼肌圆锥内注入透明质酸2 mL,术后1个月补充注射透明质酸1 mL,B组不注射药物;对照组(C组)10只,不作任何处理。比较术前和术后1个月、6个月各组左眼睑裂长度及眼眶容积差异。结果术后1个月A组、B组、C组兔左眼睑裂长度分别为(15.19±0.40)mm、(14.43±0.31)mm、(15.28±0.55)mm,术后6个月分别为(17.64±0.64)mm、(15.71±0.94)mm、(19.11±0.82)mm。术后1个月A组、B组、C组CT测量兔左眼眶容积分别为(2.30±0.14)cm^3、(1.54±0.16)cm^3、(2.40±0.09)cm^3,术后6个月分别为(4.70±0.18)cm^3、(3.18±0.17)cm^3、(4.94±0.24)cm^3。术后1个月兔左眼睑裂长度及眶容积,B组与各组间差异均有统计学意义(均为P<0.01),A、C组间差异均无统计学意义(均为P>0.05)。术后6个月兔左眼睑裂长度及眶容积,组间两两比较差异均有统计学意义(均为P<0.05)。结论肌圆锥内注射透明质酸较不注射透明质酸兔眼眶发育好,是促使眼睑及眼眶发育的有效方法。Objective To observe the orbital growth and changes of orbital volume stimulated by injecting hyaluronic acid into immature rabbits muscle cone. Methods A total of 30 New Zealand immature rabbits with 1 month old were randomly divided into 3 groups,10 cases in each group. The left eyes of rabbits in group A and B were enucleated,the right eyes were remained. Seven days later after the surgery,the left eye muscle cones of each rabbits in group A were injected 2 mL hyaluronic acid,and added 1 mL one month later. Rabbits in group B were not injected drugs,while rabbits in group C were done nothing. The left palpebral fissure length and orbital volumes were measured at preoperative and postoperative 1month,6 months. Results At postoperative 1 month,the left palpebral fissure length in group A,B and C were（ 15. 19 ± 0. 40） mm,（ 14. 43 ± 0. 31） mm,（ 15. 28 ± 0. 55） mm,respectively,which at postoperative 6 months were（ 17. 64 ± 0. 64） mm,（ 15. 71 ± 0. 94）mm,（ 19. 11 ± 0. 82） mm,respectively. At postoperative 1 month,the left orbital volumes measured by CT in group A,B and C were（ 2. 30 ± 0. 14） cm^3,（ 1. 54 ± 0. 16） cm^3,（ 2. 40± 0. 09） cm^3,respectively,which at postoperative 6 months were（ 4. 70 ± 0. 18） cm^3,（ 3.18 ± 0. 17） cm^3,（ 4. 94 ± 0. 24） cm^3,respectively. The differences in the left palpebral fissure length and orbital volumes at postoperative 1 month between group B and the other groups were statistically significant（ all P 0. 01）,the difference between group A and C was not statistically significant（ P〈 0. 05）. The differences in the left palpebral fissure length and orbital volumes at postoperative 6 months between each two groups were statistically significant（ all P〈 0. 05）. Conclusion The orbital growth with hyaluronic acid injection is better than that without injection,and it is a effective way to increase palpebral fissure length and orbital volume.

关 键 词：眼球摘除 眼眶 透明质酸 兔 

分 类 号：R575.2[医药卫生—消化系统]