提高大鼠子宫内膜异位症建模成功率的新方法  

A new method for improving the success rate of the establishment of endometriosis models in rats

作　　者：李龙卫 王艳云[1] 陈琦[1] 王亚萍[1] 韩璐[1] 

机构地区：[1]大连医科大学附属妇产医院暨大连市妇幼保健院,辽宁大连116033

出　　处：《中国比较医学杂志》2016年第3期81-85,共5页Chinese Journal of Comparative Medicine

摘　　要：目的为子宫内膜异位症治疗新方法的研究提供理想的动物模型。方法取64只性成熟、未孕、动情周期规律的SD大鼠,于动情期在腹膜、皮下利用"刀划法"行自体子宫内膜移植,术后4周比较两移植部位建模情况。结果大鼠动情期自体子宫内膜移植总体成功率为93.3%,其中腹膜移植成功率为51.7%,皮下移植成功率为88.3%,两者比较差异有统计学意义;比较两部位异位病灶的体积,差异无统计学意义。结论利用"刀划法"建立大鼠子宫内膜异位症模型成功率较高,皮下移植比腹膜移植成功率高。Objective To provide ideal endometriosis animal models for research new treatment methods.Methods 64 Sexual mature without pregnant SD rats who has regular oestrous cycle were underwent operation that autologous endometrium were transplanted to peritoneum and subcutaneous with lancet gently cut tissue of where to transplant in the rut,and compared the model of peritoneum and subcutaneous after 4 weeks. Results The general success rate of autologous endometrium transplantation in rat estrus was 93. 3%,and the peritoneum transplantation success rate was 51. 7%,subcutaneous was 88. 3%,the difference of the two place transplantation has statistical significance.Compare the two parts of volume of endometriosis,there was no statistically significant difference. Conclusion Using the lancet to establish the endometriosis model has a high success rate,and subcutaneous model is better than peritoneum.

关 键 词：子宫内膜异位症 模型 动物 动情期 啮齿 

分 类 号：R-332[医药卫生]