合用阿立哌唑及单用利培酮对精神分裂症体质量的影响  

Effects of Aripiprazole Combined with Risperidone and Risperidone on the Body Mass of Patients with Schizophrenia

作　　者：史玲[1,2] 杨云龙[2] 韩笑[2] 于丽燕[2] 严保平[2] 韩彦超[2] 周玉娟[1] 高景娜[2] 

机构地区：[1]河北大学 [2]河北省第六人民医院

出　　处：《中国健康心理学杂志》2016年第4期494-497,共4页China Journal of Health Psychology

摘　　要：目的:对比利培酮与阿立哌唑合用及单用利培酮对精神分裂症患者体重及体重指数(BMI)的影响。方法:将符合入组标准的70例精神分裂症患者随机分为阿立哌唑合并利培酮组(合用阿立哌唑组)及单用利培酮组(单一利培酮组)。两组各入组35例,在基线及4周末、8周末,用阳性和阴性症状量表(PANSS)评定疗效,并进行体重及体重指数(BMI)的测定。结果:共完成65例,合用阿立哌唑组31例,单一利培酮组34例。治疗4周末及8周末,两组PANSS评分差异均无统计学意义;治疗后两组间有明显的变化,单一利培酮组体重及BMI值均增加明显(P<0.05);组间变化值的比较,合用阿立哌唑组BMI值均较单一利培酮组低(t=2.61,P<0.05)。结论:合用阿立哌唑能够明显减轻利培酮对体质量的影响。Objective：To compare the effects of risperidone combined with aripiprazle with only use of risperidone on body weight and BMI in patients with schizophrenia.Methods：70patients with schizophrenia who met the criteria were randomized to two groups receiving risperidone combined with aripiprazle（research group）and only risperidone（control group）.Each group consists of 35 cases.Clinical efficacies and the indexes body weight and BMI in patients were assessed with PANSS at the base line and at the end of the 4th week,and 8th week.Results：There were 65 cases finishing the experiment including 31 cases of research group and 34 of control group.After the treatment of the end of the 4th week and 8th week,there were no significant differences in the scores of PANSS between two groups.There was obvious change in two groups after the treatment.In comparison with the research group,the change was higher in control group in body weight and BMI（P〈0.05）.In comparison with the control group,the body BMI was lower in research group（t=2.61,P〈0.05）.Conclusion：Risperidone combined with aripiprazole can obviously reduce the effect of risperidone on body quality.

关 键 词：阿立哌唑 利培酮 体重 体重指数 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]