天然药物防治非酒精性脂肪性肝病的研究进展  

Research advances in natural drugs for prevention and treatment of nonalcoholic fatty liver disease

作　　者：刘宝清[1] 徐秀琴[1] 门斯烨[1] 余文[1] 杨成城[1] 德吉[2] 索朗平措[2] 陈静[2] 尼玛扎巴 顿珠次仁[2] 吴伟[1] 

机构地区：[1]北京中医药大学东方医院普通外科,北京100078 [2]西藏藏医学院附属医院,拉萨850000

出　　处：《临床肝胆病杂志》2016年第3期557-560,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金资助项目(81460767)

摘　　要：非酒精性脂肪性肝病(NAFLD)是目前最常见的肝脏疾病,常常被认为是代谢综合征在肝脏的表现。目前还没有治疗NAFLD的特效药物,唯一被证实有效的治疗方式就是提供生活方式指导以减轻体质量。胰岛素抵抗、氧化应激反应、炎症反应和凋亡机制参与了NAFLD的形成,通过动物实验和人体试验证实,有多种天然药物都具有抗氧化、抗炎症或胰岛素增敏作用,对改善NAFLD疗效显著。总结了近年来常用的10种天然药物防治NAFLD的研究进展,认为未来需更多的研究来证实天然药物在NAFLN患者中所具有的疗效。At present,nonalcoholic fatty liver disease（ NAFLD） is the most common liver disease,and is often regarded as the manifestation of metabolic syndrome in the liver. There are no specific drugs for this disease at the moment,and the only therapeutic method proved effective is guiding life style to reduce body weight. Insulin resistance,oxidative stress response,inflammatory response,and apoptosis are involved in the pathogenesis of NAFLD. Animal experiments and human studies have proved that various natural drugs have antioxidant,anti- inflammatory,or insulin- sensitizing effects and thus have significant efficacy in the treatment of NAFLD. This article summarizes the research advances in 10 natural drugs commonly used for the prevention and treatment of NAFLD in recent years and treatment of NAFLD in recent years and concludes that more studies are needed to confirm the efficacy of natural drugs in NAFLD patients.

关 键 词：脂肪肝 药物疗法 综述 

分 类 号：R575.5[医药卫生—消化系统]