炎症因子在酒精性肝病发生发展中的作用  

Role of inflammatory factors in development and progression of alcoholic liver disease

作　　者：邱媛媛[1] 王伟恒[1] 朱樑[1] 

机构地区：[1]第二军医大学附属长征医院消化科,上海200003

出　　处：《临床肝胆病杂志》2016年第3期574-578,共5页Journal of Clinical Hepatology

摘　　要：酒精性肝病(ALD)是全球范围内引起肝损伤的最常见疾病。炎症反应是引起ALD肝损伤的重要原因。酒精入肠后可使肠源性内毒素经肝肠循环入血增多,进而激活肝脏Kupffer细胞中Toll样受体4引起炎症因子的释放。肿瘤坏死因子α等炎症因子引起肝损伤,而白细胞介素(IL)6、10等通过调节炎症反应起到保护肝脏的作用。其中IL-6通过激活信号转导和转录激活因子(STAT)3通路上调肝细胞中多种抗损伤基因的表达,IL-10通过激活Kupffer细胞中STAT3抑制肝脏炎症反应。促炎因子和抗炎因子的失衡和再平衡的过程就是ALD的发展和转归过程。从炎症反应角度系统的综述了炎症因子在ALD发生发展中的作用。Alcohol liver disease（ ALD） is the most common disease resulting in liver injury in the world. Inflammatory response is an important reason for liver injury in ALD. After being absorbed into the intestines,alcohol can increase the amount of intestinal endotoxin which enters the bloodstream through enterohepatic circulation and activates Toll- like receptor 4 in liver Kupffer cells to release inflammatory factors. The inflammatory factors including tumor necrosis factor- α induce liver injury,while interleukin- 6（ IL- 6） and interleukin- 10（ IL- 10） protect the liver through regulating inflammatory response. IL- 6 can increase the expression of various anti- injury genes in hepatocytes through activating signal transducer and activator of transcription 3（ STAT3）,and IL- 10 can inhibit liver inflammatory response through activating STAT3 in Kupffer cells. The processes of imbalance and rebalance between proinflammatory factors and anti- inflammatory factors are the development and prognosis of ALD. This article systematically reviews the role of inflammatory factors in the development and progression of ALD from the perspective of inflammatory response.

关 键 词：肝疾病 酒精性 肿瘤坏死因子Α 白细胞介素6 白细胞介素10 综述 

分 类 号：R575.5[医药卫生—消化系统]