转化生长因子Ⅱ型受体和Smad4在外阴鳞状细胞癌中的表达及意义  

TβRⅡ and Smad4 expression in vulvar squamous cell carcinoma and its clinical significance

作　　者：王艳实 姜英[1] 赵毅[1] 杨秀华[1] 武昕[1] 

机构地区：[1]中国医科大学附属第一医院妇科,沈阳110001

出　　处：《山西医药杂志》2016年第6期627-629,共3页Shanxi Medical Journal

基　　金：国家自然科学基金(30973190);辽宁省科学技术计划(2014021057)

摘　　要：目的探讨转化生长因子Ⅱ型受体（TβRⅡ）和Smad4蛋白与外阴鳞癌的发生发展关系。方法采用免疫组织化学方法检测TβRⅡ和Smad4在25例外阴鳞癌及15例外阴正常皮肤中的表达情况,并收集外阴鳞癌患者的临床病理资料进行分析。结果 TβRⅡ和Smad4蛋白在外阴鳞癌中的表达明显低于外阴正常皮肤（P〈0.05）;在外阴鳞癌Ⅲ期中表达明显低于Ⅰ~Ⅱ期（P〈0.05）,在有淋巴结转移中明显低于无淋巴结转移,在中低分化中表达明显低于高分化（P〈0.05）。Pearson相关性分析结果表明：TβRⅡ和Smad4在外阴鳞癌中的表达呈正相关。结论 TβRⅡ和Smad4的低表达与外阴鳞癌的发生和发展有关。Objective To investigate the expression ofTβR Ⅱand Smad4 in vulvar squamous cell carcinoma （VSCC）, and its association with occurrence and development of the disease. Methods Immunohistochemistry was conducted to detect the expression of TβR Ⅱ and Smad4 in both VSCC （n= 25） and normal vulvas tissues（n= 15）. Then we analyzed the relationship between the expression of TβR Ⅱ, Smad4 protein and clinical and patho- logical data of patients with VSCC. Results The expression of TβR Ⅱ and Smad4 in VSCC was significantly lower than that in normal vulva skin tissue（ P 〈0.05）; the expression of TβR Ⅱ and Smad4 in VSCC tissue of m stage was significantly lower than that of stage TβR Ⅱ （ P 〈0.05） ; the expression ofTβR Ⅱ and Smad4 in cases with lymph node metastasis was lower than those without lymph node metastasis（P〈0.05）;the expression ofTβR Ⅱ and Smad4 in moderately and poorly differentiated VSCC was lower than those in well differentiated VSCC（ P 〈 0.05）. The Pearson correlation analysis showed that TβR Ⅱ and Smad4 expression was positively correlated in vulva squamous cell carcinoma. Conclusion Both the low expression of TβR Ⅱand Smad4 protein were associated with occurrence and development of the VSCC.

关 键 词：外阴肿瘤 肿瘤 鳞状细胞 TβRⅡ SMAD4 免疫组织化学 

分 类 号：R737.35[医药卫生—肿瘤]