帕立哌酮与氟哌啶醇治疗首发老年期精神障碍对照观察  

A control observation of paliperidone vs. haloperidol in first-episode senile mental disorder

作　　者：赵青枫[1] 

机构地区：[1]云南省精神病医院,云南昆明650224

出　　处：《临床心身疾病杂志》2016年第2期126-127,共2页Journal of Clinical Psychosomatic Diseases

摘　　要：目的比较帕立哌酮与氟哌啶醇治疗首发老年期精神障碍的临床疗效与安全性。方法将50例老年期精神障碍患者按数字表法随机分为两组，每组25例，分别给予帕立哌酮、氟哌啶醇治疗，观察6周。于治疗前后采用阳性与阴性症状量表、副反应量表评定临床疗效及不良反应。结果治疗6周末，帕立哌酮组总有效率为96％，氟哌啶醇组为92％，两组比较差异无显著性（P〉0．05）。治疗后两组阳性与阴性症状量表总分及阳性症状、阴性症状、一般病理因子分均较治疗前显著降低（P〈0．01），治疗前后两组比较差异无显著性（P〉0．05）。帕立哌酮组不良反应程度较轻微，发生率显著低于氟哌啶醇组（P〈0．05）。结论帕立哌酮治疗首发老年期精神障碍疗效显著与氟哌啶醇相当，且不良反应轻微、安全性高，有利于提高患者的治疗依从性。Objective To compare the efficacy and safety between paliperidone and haloperidol in first-epi- sode senile mental disorder. Methods According to random table 50 senile patients with first-episode mental disorders were assigned to two groups treated with paliperidone or haloperidol for 6 weeks. Efficacies were assessed with the Positive and Negative Syndrome Scale （PANSS） before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale （TESS）. Results At the end of the 6~h week total effective rate was respectively 96% in paliperidone and 92% in haloperidol group, which showed no significant group difference （P^0.05）. After treatment the total, positive, negative symptom and general pathological factor scores of the PANSS in both groups lowered more significantly compared with pretreatment （P〈0.01）, there were no significant group differences in those （P〉0.05）. Adverse reactions were mild and their incidences significantly lower in paliperidone than in haloperidol group （P 〈 0.05）. Conclusion Both paliperidone and haloperidol have an equivalent and evident effect in first-episode senile mental disorder, but the former has mild adverse reactions and higher safety, and is beneficial to the improvement of patients treatment compliance.

关 键 词：老年期精神障碍 首次发病 帕立哌酮 氟哌啶醇 阳性与阴性症状量表 副反应量表 

分 类 号：R749.16[医药卫生—神经病学与精神病学]