钙离子阻滞剂和硝酸脂类药物与胃食管反流病关系的研究  

The relationship between calcium-channel blocker and nitrate compound and gastroesophageal reflux disease

作　　者：刘冬梅 李佳 李谨俐 卜伟 郑秀娟 王宇 徐静 

机构地区：[1]辽宁电力中心医院消化内科,沈阳110006

出　　处：《中华胃食管反流病电子杂志》2015年第2期90-92,共3页Chinese Journal Of Gastroesophageal Reflux Disease(Electronic Edition)

摘　　要：目的探讨钙离子阻滞剂和硝酸脂类药物与胃食管反流病的关系。方法根据怀疑患有胃食管反流病(GERD)的患者(107例)所服用的药物种类不同进行分组,分别为钙离子阻滞剂组、硝酸酯类组和合用组。对患者进行胃镜检查和/或PPI试验治疗以确定GERD。结果钙离子阻滞剂组、硝酸酯类组和合用组GERD发病率分别为36.67%、27.5%、55.88%,合用组GERD的发病率明显高于其他2组,3组之间比较有统计学意义(P<0.05)。结论联合应用钙离子阻滞剂组、硝酸酯类药物增加了胃食管反流病的发病率。Objective To investigate the relationship between calcium-channel blocker, nitrate compound and the gastroesophageal reflux disease. Methods Patients （ n =107 ） with GERD were divided into calcium-channel blocker,nitrate compound and the combination group,according to the different groups of drugs used in patients. Patients underwent gastroscopy and/or PPI test. Results The incidence of GERD was 36. 67%, 27. 5%, 55. 88%, and the incidence of GERD in the combination group was significantly higher than other 2 groups （ P〈0. 05 ） . Conclusion The incidence of gastroesophageal reflux disease was increased by the combination of calcium-channel blocker,nitrate compound.

关 键 词：胃食管反流病 钙离子阻滞剂 硝酸脂类药物 

分 类 号：R571[医药卫生—消化系统]