角膜生物力学分析仪测量近视患者中央角膜厚度和眼压的准确性评价  

Accuracy of Corvis ST for the measurement of central corneal thickness and intraocular pressure in myopia

作　　者：肖信[1] 刘伟民[1] 黄建忠[1] 王英[1] 

机构地区：[1]广西壮族自治区人民医院广西视光中心,南宁530021

出　　处：《中华实验眼科杂志》2016年第4期340-344,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：广西自然科学基金项目（2015GXNSFBA139148）;广西卫生厅医疗科研课题项目（桂卫Z2013345）

摘　　要：背景CorvisST角膜生物力学分析仪（CorvisST）能测量角膜生物力学指标、眼压和中央角膜厚度（CCT），且测量的眼压值为校正CCT和生物力学因素的修正值，在国外已用于临床，但目前对中国人群CCT和眼压测量准确性的研究报道较少。目的评估CorvisST测量近视患者CCT和眼压的准确性，为其临床应用提供参考。方法采用诊断性试验方法，对2012年11—12月在广西视光中心准分子激光门诊行术前检查的56例近视患者进行CorvisST、Goldmann压平式眼压计（GAT）和A型超声检查，采用配对t检验法比较CorvisST测量CCT值与A型超声测量结果的差异及CorvisST测量眼压值与GAT测量结果的差异，采用Bland·Altman法评价不同测量方法测量结果的一致性。结果CorvisST测得的CCT值为（539．82±19．79）μm，高于A型超声测量的CCT值（535．34±19．41）μm，两者比较差异有统计学意义（￡：4．19，P〈O．01）。CorvisST测得CCT均值较A型超声测量均值高4．5μm，95％的一致性界限为-11．2～20．2Ixm，7．1％（4／56）的点在95％的一致性界限以外。CorvisST和GAT测得的眼压值分别为（15．75±1．60）mmHg（1mmHg=0．133kPa）和（16．23±2．40）mmHg，两者比较差异有统计学意义（t=2．15，P=0．04）。CorvisST测得的眼压均值较GAT测得均值低0．5mmHg，95％一致性界限为-3．8—2．8mmHg，3．57％（2／56）的点在95％一致性界限以外。结论CorvisST测量的CCT稍高于A型超声，2种检测仪器测量的CCT结果一致性较差，临床上不可互相代替。CorvisST测量的眼压值稍低于GAT，二者测量值具有较好的一致性，临床上可以互相替代。Background Corvis ST corneal biomechanical analyzer （Corvis ST） can offer corneal biomechanical parameters,intraocular pressure （IOP） and central corneal thickness （CCT） ,and measured IOP value was corrected based on CCT and biomechanical factors. Corvis ST is applied abroad,but the study on its accuracy is few in China. Objective This diagnostic trial was to evaluate the accuracy of Corvis ST for CCT and lOP measurement in myopic population. Methods Fifty-six eyes from 56 myopic patients were prospective recruited in Visual Science and Optometry Center of Guangxi from November to December in 2012. IOP was measured by using Corvis ST and Goldmann applanation tonometer （GAT） ,and CCT was measured by Corvis ST and A type ultrasonic pachymetry. The CCT difference between Corvis ST and A type ultrasonic pachymetry as well as IOP between Corvis ST and GAT were compared by using paired-t test, and agreements of measured outcomes were analyzed by Bland- Altman method. This study was approved by the Ethic Committee of People/s Hospital of Guangxi and written informed consent was obtained from all subjects. Results The CCT from Corvis ST was （539.82± 19.79） μm,which wassignificantly higher than （ 535.34 ± 19.41 ）μm from A type ultrasonic pachymetry （ t = 4.19, P 〈 0. 001 ）. Bland- Altman analysis revealed that the CCT measured by Corvis ST was 4. 5 μm higher than that of A type ultrasonic pachymetry,with the 95% limit of agreement ranged from - 11.2 to 20.2 μm, and 7. 1% （4/56） of points were located at the outside of the 95% confidence interval. The IOP measured by Corvis ST and GAT were （15.75±1.60） mmHg and （ 16.23 ±2. 40） mmHg, respectively, showing statistically significant difference between the two methods （t= 2.15 ,P= 0. 04）. Bland-Airman analysis revealed that the lOP measurement of Corvis ST was 0.5 mmHg lower than that of GAT,with the 95% limit of agreement ranged from -3.8 to 2.8 mmHg, and 3.57% （2/56） of points were located at the outside of the 95% co

关 键 词：生物测量/方法 眼压测量/仪器 角膜厚度测量/方法 准确性 近视眼 人 角膜生物 力学分析仪 

分 类 号：R778.11[医药卫生—眼科]