舍曲林联合氨磺必利治疗难治性强迫症的临床研究  

Effects of Sertraline Combined with Amisulpride Treatment on Refractory Obsessive Compulsive Disorder

作　　者：万其容[1] 胡亚荣[1] 徐金枝[2] 易军[1] 

机构地区：[1]华中科技大学同济医学院附属梨园医院精神心理科,武汉430077 [2]华中科技大学同济医学院附属同济医院神经内科,武汉430030

出　　处：《神经损伤与功能重建》2016年第2期138-140,共3页Neural Injury and Functional Reconstruction

基　　金：湖北省自然科学基金(No.2012FFB02430)

摘　　要：目的:探讨舍曲林联合氨磺必利治疗难治性强迫症的临床疗效及安全性。方法:难治性强迫症患者45例,随机分为对照组23例和实验组22例。对照组单用舍曲林,实验组给予舍曲林合并氨磺必利治疗,均治疗8周。治疗前后采用耶鲁-布朗强迫量表(Y-BOCS)评定强迫症严重程度,不良反应量表(TESS)评定不良反应。结果:治疗8周后,对照组和实验组的总有效率分别为66.7%、90.1%,实验组优于对照组,差异有统计学意义(P<0.05)。治疗2周和4周后,实验组Y-BOCS评分较对照组降低(P<0.05),治疗8周末实验组的Y-BOCS评分较对照组显著降低(P<0.01)。2组组内比较,除对照组在治疗2周末与治疗前比较Y-BOCS评分差异不明显,其余各周评分与治疗前比较均有显著性差异(P<0.01)。2组的不良反应中,唾液增多差异有统计学意义(P<0.05)。结论:舍曲林联合氨磺必利治疗难治性强迫症与舍曲林单药治疗比较,起效更早、疗效更好,安全性较好。Objective： To explore the efficacy and safety of sertraline combined with amisulpride treatment on refractory obsessive-compulsive disorder（OCD）. Methods： Forty-five OCD patientswere randomly divided into groups control（n=23） and experimental（n=22）. The control group was given sertraline alone for 8 weeks, and the experimental group was given sertraline and amisulpride for 8 weeks. Before and after the treatment, Yale Brown Obsessive-Compulsive Scale（Y-BOCS） was used to assess the severity of symptoms and TESS was used to assess the adverse reactions. Results： After 8 weeks of treatment, the total effective rate of the control and experimental groups were 66.7% and 90.1%. At 2 and 4 weeks of treatment, Y-BOCS score of the experimental group was lower than that of the control group（P〈0.05）. At 8 weeks of treatment, the Y-BOCS score in the experimental group was significantly lower than that in the control group（P〈0.01）. For intra-group comparison of the both groups, Y-BOCS score at each week of treatment decreased significantly compared with the score before treatment（P〈0.01）, except for at 2 weeks of treatment in the control group（no significant difference compared with the score before treatment）. In light of the adverse reactions, increased salivation showed a significant difference between the 2 groups（P〈0.05）. Conclusion： Sertraline combined with amisulpride treatment on refractory OCD is better than sertraline monotherapy, showing earlier start of therapeutic efficacy, higher effective rate and more safe.

关 键 词：难治性强迫症 舍曲林 氨磺必利 

分 类 号：R741[医药卫生—神经病学与精神病学] R749.053[医药卫生—临床医学]