发作性睡病药物治疗进展  

Study Advance of Drug Therapy in Narcolepsy

作　　者：郝茂林[1] 商笑[1] 冯建利[1] 刘菲[1] 杜怡峰[1] 

机构地区：[1]山东大学附属省立医院神经内科,济南250022

出　　处：《医学综述》2016年第7期1305-1309,共5页Medical Recapitulate

摘　　要：发作性睡病是一种慢性睡眠障碍,多数患者需要长期药物治疗,传统的兴奋药物用于治疗日间过度嗜睡,抗抑郁剂用于猝倒发作的治疗。一些新型药物如莫达非尼、阿莫达非尼和羟丁酸钠已经应用于临床,另外一些新药正在试验过程中,主要包括下视丘分泌素激动剂、黑色素受体拮抗剂和组胺H_3受体拮抗剂。目前发作性睡病的患者主要根据症状选择药物,当然要考虑到药物的不良反应及注意事项。Narcolepsy is a chronic sleep disorder,and most patients need life-long treatment. Traditionally,amphetamine-like stimulants have been used for clinical management to improve excessive daytime sleepiness,whereas antidepressants have been used as anticataplectics. However,treatments have evolved to bettertolerated compounds such as modafinil or armodafinil,sodium oxybate,which have been used for the treatment for narcolepsy. Some other new drugs are currently being tested,including hypocretin agonists,melaninconcentrating hormone receptor antagonists,and histamine H3 receptor antagonists. Now patients select drugs according to symptoms,with the adverse effects and notice of the drugs considered.

关 键 词：发作性睡病 下视丘脑分泌素 药物治疗 

分 类 号：R741[医药卫生—神经病学与精神病学]