阿立哌唑联合齐拉西酮治疗精神分裂症的效果及对血脂的影响  

The effect of aripiprazole and ziprasidone in treatment of schizophrenia and its effect on blood lipid

作　　者：邱继红[1] 牟元云[1] 

机构地区：[1]重庆市精神卫生中心,重庆401147

出　　处：《中国现代医生》2016年第7期78-80,共3页China Modern Doctor

摘　　要：目的研究阿立哌唑联合齐拉西酮治疗精神分裂症的效果及对血脂的影响。方法选取2014年7月～2015年5月在我院收治的精神分裂症患者86例作为研究对象,随机分为对照组和观察组,对照组予齐拉西酮治疗,观察组在对照组的基础上予阿立哌唑治疗,比较两组的治疗效果及血脂水平情况。结果观察组患者的总有效率高于对照组,差异有统计学意义（P〈0.05）。治疗后两组患者的TC、TG、LDL-C与治疗前比较,差异无统计学意义（P〉0.05）,且治疗后两组患者的TC、TG、LDL-C比较,差异无统计学意义（P〉0.05）。观察组的不良反应发生率为44.19%,对照组为39.53%,差异无统计学意义（P〉0.05）。结论阿立哌唑联合齐拉西酮治疗精神分裂症效果更佳,对血脂无明显影响。Objective To study the effect of aripiprazole combined with ziprasidone in the treatment of schizophrenia and the effect on blood lipid. Methods The 86 patients with schizophrenia who were treated in our hospital from July2014 to May 2015 as research objects, were randomly divided into the control group and the observation group. The control group was treated with ziprasidone, while the observation group was treated with aripiprazole on the basis of the control group. The treatment effect and blood lipid levels were compared between two groups. Results The total efficiency of observation group was higher than the control group, and there was significant difference between two groups（P〈0.05）. After treatment, the changes of TC, TG and LDL-C had no statistical difference compared with before treatment（P〈0.05）. Besides, the TC, TG and LDL-C were also no significant difference between the two groups after treatment（P〈0.05）. The adverse reaction incidence of the observation group was 44.19%, while the control group was39.53%,there was no significant difference between the two groups（P〈0.05）. Conclusion Aripiprazole combined with ziprasidone is more effective in the treatment of schizophrenia disease and has no obvious effect on blood lipid.

关 键 词：阿立哌唑 齐拉西酮 精神分裂症 血脂 

分 类 号：R749.3[医药卫生—神经病学与精神病学]