丹参酮ⅡA磺酸钠对烧伤植皮创面愈合及瘢痕形成的影响  

Effect of Sodium Tanshinone IIA Sulfonate Injection on Wound Healing of Burns Skingrafting Wounds and Scar Formation

作　　者：刘嘉楠[1] 何放[1] 钱明元 郑小鹏[1] 罗鹏飞[1] 王亮[1] 程大胜[1] 唐洪泰[1] 常菲[1] 路卫[1] 

机构地区：[1]第二军医大学长海医院全军烧伤中心,上海200433 [2]张家港市第一人民医院烧伤整形科,江苏张家港215600

出　　处：《现代生物医学进展》2016年第7期1306-1308,共3页Progress in Modern Biomedicine

基　　金：上海市自然科学基金项目(15ZR1413400)

摘　　要：目的:探讨丹参酮IIA磺酸钠注射液对烧伤患者植皮创面愈合及瘢痕形成情况的影响。方法:选取2014年3月至2014年12月我院收治的烧伤植皮患者62例,根据临床用药分为试验组(使用丹参酮IIA磺酸钠注射组)与对照组(未使用丹参酮IIA磺酸钠注射液)。比较两组创面愈合情况,术后植皮成活率及愈合后瘢痕形成情况。结果:1经治疗,两组创面均愈合,试验组患者植皮成活率为(97.12±1.89)%,高于对照组(89.96±1.86)%,差异具有统计学意义(P<0.01);试验组愈合时间较对照组短,试验组创面愈合时间为10.1±1.9天,对照组为14.3±2.3天,两组比较差异具有统计学意义(P<0.001);瘢痕形成评价试验组均优于对照组,差异具有统计学意义,其中血肿面积(1.50±0.03 vs.3.04±0.08,P<0.01)、畸形率[2(6.45)vs.8(25.81),P<0.05]、感染率[2(6.45)vs.9(29.03),P<0.05]。结论:丹参酮IIA磺酸钠注射液对于烧伤植皮创面的患者,能够提高植皮成活率,促进创面愈合,减轻瘢痕形成,改善创面愈合质量。Objective： To explore the effect of Sodium tanshinone IIA sulfonate injection on success rate of skin grafting and fibrotic scar formation in burn wound healing. Methods： A total of 62 burn inpatients administrated with skin grafting from March 2014 to December 2014 in our ward were selected and divided into control group and experimental group, according to the clinical medication of Sodium tanshinone IIA sulfonate injection whether or not. The time of wound healing, scarring and the graft survival rate were compared between the two groups. Results： After the treatments, the patients in the two groups achieved complete wound healing. The graft survival rate of experimental group was higher than that of the control group [（97.12±1.89） % vs.（89.96±1.86） %, P 0.01]. The healing time of experimental group was shorter than that of the control group（10.1±1.9 d vs. 14.3±2.3 d, P 0.001）, scar formation assessment was better in the experimental group than control group, including Hematoma area（1.50±0.03 vs. 3.04±0.08, P 0.01）, aberration rate[2（6.45） vs. 8（25.81）, P 0.05] and infection rate[2（6.45） vs. 9（29.03）, P 0.05]. Conclusions： For skin garfing wounds of burn patients,sodium tanshinone IIA sulfonate injection can promote wound healing process, reduce scar formation and improve the success rate of skin grafting.

关 键 词：丹参酮ⅡA磺酸钠注射液 植皮 瘢痕 

分 类 号：R62[医药卫生—整形外科] R619.6[医药卫生—外科学]