国家自然科学基金(81401596);Supported by National Natural Science Foundation of China(81401596);上海市自然科学基金(13ZR1408800);Natural Science Foundation of Shanghai(13ZR1408800);第二军医大学长海医院"1255"学科建设计划(CH125540600);the"1255"Discipline Construction Project of Changhai Hospital of Second Military Medical University(CH125540600)