阿米洛利对脑梗死急性期患者血清炎症因子水平的影响  

Effect of Amiloride on the Levels of Inflammatory Cytokines in Patients with Acute Cerebral Infarction

作　　者：刘晓荣[1] 肖东芳 聂桐 孙健[1] 刘媛媛[1] 张皇 

机构地区：[1]铁岭市中心医院神经内科,辽宁铁岭112000 [2]辽宁中医药大学附属医院干部循环内科,辽宁沈阳110033

出　　处：《现代生物医学进展》2016年第7期1325-1327,1362,共4页Progress in Modern Biomedicine

基　　金：辽宁省自然科学基金项目(201102296)

摘　　要：目的:探讨阿米洛利对脑梗死急性期患者血清ox-LDL、炎症因子及MMP-9水平影响及其意义。方法:选取我院诊治的急性脑梗死患者120例,随机分为对照组和实验组,每组60例。两组患者均给予常规对症治疗,实验组在对照组的治疗基础上加用盐酸阿米洛利片。采用酶联免疫吸附法(ELISA)及免疫透射比浊法分别测定两组患者血清ox-LDL、炎症因子及MMP-9水平,并对患者神经功能缺损程度进行评分。结果:治疗后,两组患者神经功能均较治疗前明显改善,且实验组明显优于对照组,差异均具有统计学意义(P<0.05);治疗后,两组患者血清ox-LDL及MMP-9水平均低于治疗前,且实验组低于对照组,差异具有统计学意义(P<0.05);治疗后,两组患者血清炎症因子TNF-α、IL-6及hs-CRP水平均低于治疗前,且实验组低于对照组,差异具有统计学意义(P<0.05)。结论:阿米洛利能够降低脑梗死急性期患者ox-LDL、TNF-α、IL-6、hs-CRP及MMP-9水平,减轻炎症反应,改善患者的神经功能。Objective： To investigate the effect of amiloride on the serum level of ox-LDL, inflammatory cytokines and MMP-9 in the patients with acute cerebral infarction. Methods： 120 acute cerebral infarction patients from our hospital were selected and randomly divided into the control group and the experiment group, 60 cases each group. The patients in two groups were treated by conventional symptomatic treatment, and the patients in experiment group were treated with Amiloride Hydrochloride Tablets on the base of conventional treatment. The levels of ox-LDL, inflammatory factors and MMP-9, the degree of neurological function impairment were tested by ELISA and compared between two groups. Results： After treatment, the neurological function of the two groups significantly improved,and the experimental group was significantly better than that of the control group, and the difference was statistically significant（P0.5）;after treatment, the levels of ox-LDL and MMP-9 in the two groups were lower than before treatment, and the experimental group was significantly lower than that of the control group（P0.05）; after treatment, the levels of TNF-α, IL-6 and hs-CRP in the two groups were lower than before treatment, and they were lower in the experimental group than that of the control group, and the difference was statistically significant（P0.05）. Conclusions： Amiloride can reduce the inflammatory factors in patients with acute cerebral infarction and relieve inflammation reaction, and improve the neurological function of patients.

关 键 词：急性脑梗死 盐酸阿米洛利 氧化低密度脂蛋白 炎症因子 MMP-9 

分 类 号：R743[医药卫生—神经病学与精神病学]