帕罗西汀对慢性萎缩性胃炎患者血清胃泌素和胃动素水平的影响  

Effect of Paroxetine on the Serum Levels of GAS and MOT in Patients with Chronic Atrophic Gastritis

作　　者：赵威[1] 鲁英杰[1] 黄爱洁[2] 王新[1] 杨梅[3] 

机构地区：[1]辽宁中医药大学附属第四医院老年病科,辽宁沈阳110101 [2]辽宁中医药大学附属第四医院心脏病科,辽宁沈阳110101 [3]辽宁中医药大学附属第四医院血液透析科,辽宁沈阳110101

出　　处：《现代生物医学进展》2016年第8期1487-1489,共3页Progress in Modern Biomedicine

基　　金：辽宁省科技攻关课题(2013225220)

摘　　要：目的:探讨帕罗西汀对慢性萎缩性胃炎患者血清胃泌素和胃动素水平的影响及临床意义。方法:选取我院收治的80例慢性萎缩性胃炎患者,根据治疗方案不同分为常规组及试验组。常规组采用奥美拉唑治疗,试验组采用帕罗西汀治疗,观察并比较两组患者治疗前后血清胃酸度、总酸排出量、复发率、胃动素及胃泌素水平的变化情况。结果:与治疗前比较,两组患者治疗后胃酸及总酸排出量均升高,胃动素及胃泌素水平均降低,且试验组患者胃酸及总酸排出量明显高于常规组,胃动素及胃泌素水平明显低于常规组,差异均具有统计学意义(P<0.05)。治疗后,试验组复发率为7.5%(3/40),常规组复发率为30.0%(12/40),试验组复发率明显低于常规组,差异具有统计学意义(P<0.05)。结论:帕罗西汀可促进慢性萎缩性胃炎患者血清胃泌素及胃动素水平的改善,可作为临床治疗慢性萎缩性胃炎的有效方案。To investigate the effects of paroxetine on the expressions of gastrin and motilin in patients with chronic atrophic gastritis. Methods： 80 patients with chronic atrophic gastritis who were treated in our hospital were selected and according to the different treatment methods, the patients were divided into the control group and the experimental group. The patients in the control group were treated with omeprazole, while the patients in the experimental group were treated with paroxetine. Then the hydrochloric acid, relapse rate, motilin and gastrin levels in the two groups were observed and compared before and after the treatment. Results：Compared with before treatment, the levels of gastric acid and total acid output increased in the two groups after treatment, the levels of motilin and gastrin decreased（P〈0.05）; The levels of gastric acid and total acid excretion in the experimental group were significantly higher than those of the control group, and the levels of motilin and gastrin were significantly lower than those of the control group, and the differences were statistically significant（P〈0.05）. After treatment, the recurrence rate was 7.5%（3/40） in the experimental group,which was lower than 30%（12/40） in the control group, and the difference was statistically significant（P〈0.05）. Conclusions： Paroxetine can improve chronic atrophy gastritis serum gastrin and motilin levels, as an effective solution to the clinical treatment of chronic atrophic gastritis.

关 键 词：慢性萎缩性胃炎 帕罗西汀 胃动素 胃泌素 

分 类 号：R573.32[医药卫生—消化系统]