生物材料植入感染与表皮葡萄球菌生物膜形成的相关基因调控  

Biomaterial implantation associted infection and related gene regulation of biofilm formation by Staphylococcus epidermidis

作　　者：邱良婷 叶联华[1] 黄云超[1] 

机构地区：[1]昆明医科大学第三附属医院胸心外科,650118

出　　处：《国际生物医学工程杂志》2016年第1期37-42,共6页International Journal of Biomedical Engineering

基　　金：国家自然科学基金（81260228,81460278）;云南省自然科学基金（2013FZ267,2014FA048）;云南省高层次人才培养基金项目（No.2012HB032,D.201222）

摘　　要：表皮葡萄球菌是寄居于人体皮肤和黏膜表面的共生菌群,现已发现其是引发临床生物材料相关感染的主要条件致病菌,在生物材料植入感染中占有重要地位.医用生物材料表面细菌生物膜的形成是其主要致病因素,细菌生物膜可有效抵御机体的防御反应和抗生素治疗,导致生物材料植入感染难以彻底治愈,使感染呈慢性、持续性和反复性特点,从而在临床上造成了极高的死亡率.就表皮葡萄球菌生物膜的形成、胞间黏附素基因（ica）操纵子和附属基因调节子（agr）基因对表皮葡萄球菌生物膜的调控及其在临床生物材料植入感染中的作用等方面作一综述.Staphylococcus epidermidis is a commensal bacteria which inhabits on the surface of human skin and mucous membrane.It has been demonstrated that staphylococcus epidermidis is a major opportunistic pathogen that can cause clinical biomaterial related infection and plays an important role in biomaterial implantation associated infections.The main pathogenic factor is the formation of the bacterial biofilm on surface of medical biomaterial.The formation of bacterial biofilm can resist the defense reaction and antibiotic treatment effectively so that leading to the biomaterial implantation associated infection which is difficult to cure thoroughly,and make the infections become chronic,persistent and repetitive.Nowadays,the infections caused by Staphylococcus epidermidis have caused high clinical mortality.Staphylococcus epidermidis biofilm formation,the regulations of intercellular adhesion gene （ica） operon and accessory gene regulator （agr） gene on the formation of biofilm and their functions in clinical biomaterial related infections are reviewed in this article.

关 键 词：表皮葡萄球菌 生物膜 ICA操纵子 agr基因 生物材料 

分 类 号：R743.31[医药卫生—神经病学与精神病学]